Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses H Ohtaki, JH Ylostalo, JE Foraker, AP Robinson, RL Reger, S Shioda, ... Proceedings of the National Academy of Sciences 105 (38), 14638-14643, 2008 | 512 | 2008 |
Lipopolysaccharide‐induced microglial activation induces learning and memory deficits without neuronal cell deathin rats S Tanaka, M Ide, T Shibutani, H Ohtaki, S Numazawa, S Shioda, ... Journal of neuroscience research 83 (4), 557-566, 2006 | 282 | 2006 |
Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6 H Ohtaki, T Nakamachi, K Dohi, Y Aizawa, A Takaki, K Hodoyama, S Yofu, ... Proceedings of the National Academy of Sciences 103 (19), 7488-7493, 2006 | 226 | 2006 |
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury K Dohi, H Ohtaki, T Nakamachi, S Yofu, K Satoh, K Miyamoto, D Song, ... Journal of neuroinflammation 7, 1-11, 2010 | 192 | 2010 |
Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment S Shioda, H Ohtaki, T Nakamachi, K Dohi, JUN Watanabe, S Nakajo, ... Annals of the New York Academy of Sciences 1070 (1), 550-560, 2006 | 184 | 2006 |
Hydrogen peroxide-mediated degradation of protein: different oxidation modes of copper-and iron-dependent hydroxyl radicals on the degradation of albumin T Kocha, M Yamaguchi, H Ohtaki, T Fukuda, T Aoyagi Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 1997 | 153 | 1997 |
Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury A Sato, H Ohtaki, T Tsumuraya, D Song, K Ohara, M Asano, Y Iwakura, ... Journal of neuroinflammation 9, 1-17, 2012 | 138 | 2012 |
Role of PACAP in ischemic neural death H Ohtaki, T Nakamachi, K Dohi, S Shioda Journal of Molecular Neuroscience 36, 16-25, 2008 | 132 | 2008 |
Activation of microglia induces symptoms of Parkinson’s disease in wild-type, but not in IL-1 knockout mice S Tanaka, A Ishii, H Ohtaki, S Shioda, T Yoshida, S Numazawa Journal of neuroinflammation 10, 1-11, 2013 | 130 | 2013 |
Elevated plasma levels of bilirubin in patients with neurotrauma reflect its pathophysiological role in free radical scavenging K Dohi, K Satoh, H Ohtaki, S Shioda, Y Miyake, M Shindo, T Aruga In Vivo 19 (5), 855-860, 2005 | 125 | 2005 |
Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models D Dogrukol-Ak, VB Kumar, JS Ryerse, SA Farr, S Verma, N Nonaka, ... Journal of Cerebral Blood Flow & Metabolism 29 (2), 411-422, 2009 | 100 | 2009 |
PACAP suppresses dry eye signs by stimulating tear secretion T Nakamachi, H Ohtaki, T Seki, S Yofu, N Kagami, H Hashimoto, ... Nature communications 7 (1), 12034, 2016 | 97 | 2016 |
Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways K Dohi, H Mizushima, S Nakajo, H Ohtaki, S Matsunaga, T Aruga, ... Regulatory peptides 109 (1-3), 83-88, 2002 | 93 | 2002 |
Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin‐1 H Mizushima, CJ Zhou, K Dohi, R Horai, M Asano, Y Iwakura, ... Journal of Comparative Neurology 448 (2), 203-216, 2002 | 86 | 2002 |
Progressive expression of vascular endothelial growth factor (VEGF) and angiogenesis after chronic ischemic hypoperfusion in rat H Ohtaki, T Fujimoto, T Sato, K Kishimoto, M Fujimoto, M Moriya, S Shioda Brain Edema XIII, 283-287, 2006 | 81 | 2006 |
Stroke upregulates TNFα transport across the blood–brain barrier W Pan, Y Ding, Y Yu, H Ohtaki, T Nakamachi, AJ Kastin Experimental neurology 198 (1), 222-233, 2006 | 80 | 2006 |
Peroxynitrite and caspase-3 expression after ischemia/reperfusion in mouse cardiac arrest model K Dohi, H Ohtaki, R Inn, Y Ikeda, HS Shioda, T Aruga Brain Edema XII: Proceedings of the 12 th International Symposium, Hakone …, 2003 | 66 | 2003 |
Role of PACAP in neural stem/progenitor cell and astrocyte: from neural development to neural repair T Nakamachi, J Farkas, J Watanabe, H Ohtaki, K Dohi, S Arata, S Shioda Current pharmaceutical design 17 (10), 973-984, 2011 | 65 | 2011 |
Delayed expressed TNFR1 co-localize with ICAM-1 in astrocyte in mice brain after transient focal ischemia L Yin, H Ohtaki, T Nakamachi, Y Kudo, R Makino, S Shioda Neuroscience letters 370 (1), 30-35, 2004 | 63 | 2004 |
Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1 H Ohtaki, H Funahashi, K Dohi, T Oguro, R Horai, M Asano, Y Iwakura, ... Neuroscience research 45 (3), 313-324, 2003 | 61 | 2003 |