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Weihe Zhang
Weihe Zhang
The University of North Carolina at Chapel Hill, Ohio University, Shanghai University
Verified email at ohio.edu
Title
Cited by
Cited by
Year
A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
Y Liu, Y Cao, W Zhang, S Bergmeier, Y Qian, H Akbar, R Colvin, J Ding, ...
Molecular cancer therapeutics 11 (8), 1672-1682, 2012
5702012
MERTK receptor tyrosine kinase is a therapeutic target in melanoma
J Schlegel, MJ Sambade, S Sather, SJ Moschos, AC Tan, A Winges, ...
The Journal of clinical investigation 123 (5), 2257-2267, 2013
1492013
UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor
W Zhang, D DeRyckere, D Hunter, J Liu, MA Stashko, KA Minson, ...
Journal of medicinal chemistry 57 (16), 7031-7041, 2014
1432014
Small compound inhibitors of basal glucose transport inhibit cell proliferation and induce apoptosis in cancer cells via glucose-deprivation-like mechanisms
Y Liu, W Zhang, Y Cao, Y Liu, S Bergmeier, X Chen
Cancer letters 298 (2), 176-185, 2010
912010
UNC1062, a new and potent Mer inhibitor
J Liu, W Zhang, MA Stashko, D DeRyckere, CT Cummings, D Hunter, ...
European journal of medicinal chemistry 65, 83-93, 2013
832013
Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors
W Zhang, D Zhang, MA Stashko, D DeRyckere, D Hunter, D Kireev, ...
Journal of medicinal chemistry 56 (23), 9683-9692, 2013
802013
Novel inhibitors of basal glucose transport as potential anticancer agents
W Zhang, Y Liu, X Chen, SC Bergmeier
Bioorganic & medicinal chemistry letters 20 (7), 2191-2194, 2010
762010
Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis
W Zhang, AL McIver, MA Stashko, D DeRyckere, BR Branchford, D Hunter, ...
Journal of medicinal chemistry 56 (23), 9693-9700, 2013
642013
UNC2025, a MERTK small-molecule inhibitor, is therapeutically effective alone and in combination with methotrexate in leukemia models
D DeRyckere, AB Lee-Sherick, MG Huey, AA Hill, JW Tyner, ...
Clinical Cancer Research 23 (6), 1481-1492, 2017
632017
The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia
KA Minson, CC Smith, D DeRyckere, C Libbrecht, AB Lee-Sherick, ...
JCI insight 1 (3), 2016
592016
Small molecule inhibition of MERTK is efficacious in non–small cell lung cancer models independent of driver oncogene status
CT Cummings, W Zhang, KD Davies, GD Kirkpatrick, D Zhang, ...
Molecular cancer therapeutics 14 (9), 2014-2022, 2015
592015
Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia
AB Lee-Sherick, W Zhang, KK Menachof, AA Hill, S Rinella, G Kirkpatrick, ...
Oncotarget 6 (9), 6722, 2015
492015
Discovery of macrocyclic pyrimidines as MerTK‐specific inhibitors
AL McIver, W Zhang, Q Liu, X Jiang, MA Stashko, J Nichols, MJ Miley, ...
ChemMedChem 12 (3), 207-213, 2017
292017
The small‐molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis
BR Branchford, TJ Stalker, L Law, G Acevedo, S Sather, C Brzezinski, ...
Journal of thrombosis and haemostasis 16 (2), 352-363, 2018
282018
Design and synthesis of novel macrocyclic Mer tyrosine kinase inhibitors
X Wang, J Liu, W Zhang, MA Stashko, J Nichols, MJ Miley, J Norris-Drouin, ...
ACS medicinal chemistry letters 7 (12), 1044-1049, 2016
252016
Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity
X Wang, W Zhang, S Frye
US Patent 9,649,309, 2017
212017
Highly selective MERTK inhibitors achieved by a single methyl group
J Zhao, D Zhang, W Zhang, MA Stashko, D DeRyckere, E Vasileiadi, ...
Journal of Medicinal Chemistry 61 (22), 10242-10254, 2018
202018
Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma
JP Wong, TJ Stuhlmiller, LC Giffin, C Lin, R Bigi, J Zhao, W Zhang, ...
Proceedings of the National Academy of Sciences 116 (33), 16541-16550, 2019
172019
Berotralstat (BCX7353): structure-guided design of a potent, selective, and oral plasma kallikrein inhibitor to prevent attacks of hereditary angioedema (HAE)
PL Kotian, M Wu, S Vadlakonda, V Chintareddy, P Lu, L Juarez, ...
Journal of Medicinal Chemistry 64 (17), 12453-12468, 2021
162021
Superstable magnetic nanoreactors with high efficiency for Suzuki-coupling reactions
W Zhang, X Chen, T Tang, E Mijowska
Nanoscale 6 (21), 12884-12889, 2014
162014
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