Isaac Alexander Chaim
Isaac Alexander Chaim
Postdoctoral Fellow. Sanford Consortium for Regenerative Medicine. UC San Diego. La Jolla, CA
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Complex oscillatory waves emerging from cortical organoids model early human brain network development
CA Trujillo, R Gao, PD Negraes, J Gu, J Buchanan, S Preissl, A Wang, ...
Cell stem cell 25 (4), 558-569. e7, 2019
Elimination of toxic microsatellite repeat expansion RNA by RNA-targeting Cas9
R Batra, DA Nelles, E Pirie, SM Blue, RJ Marina, H Wang, IA Chaim, ...
Cell 170 (5), 899-912. e10, 2017
Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis
ZD Nagel, CM Margulies, IA Chaim, SK McRee, P Mazzucato, A Ahmad, ...
Proceedings of the National Academy of Sciences 111 (18), E1823-E1832, 2014
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment
CA Trujillo, ES Rice, NK Schaefer, IA Chaim, EC Wheeler, AA Madrigal, ...
Science 371 (6530), eaax2537, 2021
DNA repair capacity in multiple pathways predicts chemoresistance in glioblastoma multiforme
ZD Nagel, GJ Kitange, SK Gupta, BA Joughin, IA Chaim, P Mazzucato, ...
Cancer research 77 (1), 198-206, 2017
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
JM Einstein, M Perelis, IA Chaim, JK Meena, JK Nussbacher, AT Tankka, ...
Molecular cell 81 (15), 3048-3064. e9, 2021
Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes
KW Brannan, IA Chaim, RJ Marina, BA Yee, ER Kofman, DA Lorenz, ...
Nature methods 18 (5), 507-519, 2021
Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research
ZD Nagel, IA Chaim, LD Samson
DNA repair 19, 199-213, 2014
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells
T Koga, IA Chaim, JA Benitez, S Markmiller, AD Parisian, RF Hevner, ...
Nature communications 11 (1), 550, 2020
In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities
IA Chaim, ZD Nagel, JJ Jordan, P Mazzucato, LD Samson
Proceedings of the National Academy of Sciences 114 (48), E10379-E10388, 2017
Evaluation of the potential of novel PCL–PPDX biodegradable scaffolds as support materials for cartilage tissue engineering
IA Chaim, MA Sabino, M Mendt, AJ MŘller, D Ajami
Journal of tissue engineering and regenerative medicine 6 (4), 272-279, 2012
Nitric oxide induced S-nitrosation causes base excision repair imbalance
MC Parrish, IA Chaim, ZD Nagel, SR Tannenbaum, LD Samson, ...
DNA repair 68, 25-33, 2018
A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine
IA Chaim, A Gardner, J Wu, T Iyama, DM Wilson III, LD Samson
Nucleic Acids Research 45 (6), 3242-3252, 2017
CometChip analysis of human primary lymphocytes enables quantification of inter-individual differences in the kinetics of repair of oxidative DNA damage
LP Ngo, S Kaushal, IA Chaim, P Mazzucato, C Ricciardi, LD Samson, ...
Free Radical Biology and Medicine 174, 89-99, 2021
MECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy
KH Morelli, W Jin, S Shathe, AA Madrigal, KL Jones, JL Schwartz, ...
Science translational medicine 14 (651), eabn2375, 2022
Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms
CM Margulies, IA Chaim, A Mazumder, J Criscione, LD Samson
PloS one 12 (9), e0184619, 2017
Assessing BER capacity in the human population
IA Chaim, ZD Nagel
The Base Excision Repair Pathway: Molecular Mechanisms and Role in Diseaseá…, 2017
Il sistema al momento non pu˛ eseguire l'operazione. Riprova pi¨ tardi.
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