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Silvia Maria Lavezzi
Silvia Maria Lavezzi
Associate Scientific Director, CPMS, Parexel
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Anno
Current mathematical models for cancer drug discovery
L Carrara, SM Lavezzi, E Borella, G De Nicolao, P Magni, I Poggesi
Expert opinion on drug discovery 12 (8), 785-799, 2017
272017
Mathematical modeling of efficacy and safety for anticancer drugs clinical development
SM Lavezzi, E Borella, L Carrara, G De Nicolao, P Magni, I Poggesi
Expert Opinion on Drug Discovery 13 (1), 5-21, 2018
92018
Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial
SM Lavezzi, J de Jong, M Neyens, P Cramer, F Demirkan, G Fraser, ...
Pharmaceutical research 36 (7), 93, 2019
52019
MPBPK-TMDD models for mAbs: alternative models, comparison, and identifiability issues
SM Lavezzi, E Mezzalana, S Zamuner, G De Nicolao, P Ma, M Simeoni
Journal of pharmacokinetics and pharmacodynamics 45 (6), 787-802, 2018
42018
The area under the effect curve as an efficacy determinant for anti‐infectives
C Chen, SM Lavezzi, L Iavarone
CPT: Pharmacometrics & Systems Pharmacology, 2022
32022
Concept and application of the probability of pharmacological success (PoPS) as a decision tool in drug development: a position paper
C Chen, X Zhou, SM Lavezzi, U Arshad, R Sharma
Journal of Translational Medicine 21 (1), 1-13, 2023
22023
Translational modelling and estimation of probability of molecule success on balance of pharmacology benefit and safety risk
SM Lavezzi, C Chen, J Upson, J Toomey, K French, L Chen, A Lindsay
22021
Assessing drug effect from distributional data: a population approach with application to Duchenne Muscular Dystrophy treatment
SM Lavezzi, M Rocchetti, P Bettica, S Petrini, G De Nicolao
Computer Methods and Programs in Biomedicine, 2019
22019
Systemic Exposure of Rituximab Increased By Ibrutinib: Pharmacokinetic Results from the Helios Trial
P Cramer, F Demirkan, G Fraser, A Pristupa, NL Bartlett, MS Dilhuydy, ...
Blood 128 (22), 4403-4403, 2016
22016
IBRUTINIB INCREASES THE SYSTEMIC EXPOSURE OF RITUXIMAB: PHARMACOKINETIC RESULTS FROM THE HELIOS TRIAL
P Cramer, F Demirkan, G Fraser, A Pristupa, N Bartlett, M Dilhuydy, ...
Hematological Oncology 35 (S2), 232-233, 2017
12017
A SIMULATION-BASED EVALUATION OF THE AREA UNDER THE EFFECT CURVE AS AN EFFICACY DRIVER FOR ANTI-INFECTIVES
C Chen, L Iavarone, S Lavezzi
CLINICAL PHARMACOLOGY & THERAPEUTICS 109, S9-S9, 2021
2021
Pharmacokinetic models for drug and metabolites including first pass effects
SM Lavezzi, J Zhang, P Magni, G De Nicolao, L Iavarone
2019
IV-20 Paolo Magni Evaluation of software tools for Bayesian estimation on population models: an update based on current software versions
R Bartolucci, SM Lavezzi, EM Tosca, N Melillo, S Grandoni, E Borella, ...
2018
Analysis of muscular biopsy distributional data in Duchenne Muscular Dystrophy treatment: a population approach
SM Lavezzi, M Rocchetti, P Bettica, S Petrini, G De Nicolao
PAGE 27, 2018
2018
Modelling of Rituximab Clearance Reduction Due to Ibrutinib Co-administration
SM Lavezzi, J de Jong, M Neyens, P Cramer, F Demirkan, G Fraser, ...
2017
I-51 Italo Poggesi A Shiny App for the Probability of Technical Success of a New Molecular Entity in the Preclinical to Clinical Translational Phase
SM Lavezzi, Y Cherkas, N Haddish-Berhane, S Jagannatha, ...
2017
Structural and practical identifiability of some mPBPK-TMDD models
SM Lavezzi, S Zamuner, G De Nicolao, P Ma, M Simeoni
PAGE 25, 2016
2016
Methods and tools for multiscale modelling in Systems Pharmacology: a review
E Borella, L Carrara, SM Lavezzi, I Massaiu, E Sauta, EM Tosca, F Vitali, ...
PAGE 25, 2016
2016
IV-23 Enrica Mezzalana Integrating Target Mediated Drug Disposition (TMDD) into a minimal physiologically based modelling framework: evaluation of different quasi-steady-state …
E Mezzalana, SM Lavezzi, S Zamuner, G De Nicolao, P Ma, M Simeoni
2015
Toxicity assessment via drug-drug interaction modeling for trabectedin patients with advanced malignancies
SM Lavezzi, E Mezzalana, G De Nicolao
2015
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