Antonio Macchiarulo
Antonio Macchiarulo
Full Professor, University of Perugia
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TGR5-mediated bile acid sensing controls glucose homeostasis
C Thomas, A Gioiello, L Noriega, A Strehle, J Oury, G Rizzo, ...
Cell metabolism 10 (3), 167-177, 2009
Aryl hydrocarbon receptor control of a disease tolerance defence pathway
A Bessede, M Gargaro, MT Pallotta, D Matino, G Servillo, C Brunacci, ...
Nature 511 (7508), 184-190, 2014
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
E Wahlberg, T Karlberg, E Kouznetsova, N Markova, A Macchiarulo, ...
Nature biotechnology 30 (3), 283-288, 2012
Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure− activity relationships, and molecular modeling studies
H Sato, A Macchiarulo, C Thomas, A Gioiello, M Une, AF Hofmann, ...
Journal of medicinal chemistry 51 (6), 1831-1841, 2008
A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells
G Mondanelli, R Bianchi, MT Pallotta, C Orabona, E Albini, A Iacono, ...
Immunity 46 (2), 233-244, 2017
Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity
R Pellicciari, A Gioiello, A Macchiarulo, C Thomas, E Rosatelli, B Natalini, ...
Journal of medicinal chemistry 52 (24), 7958-7961, 2009
Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1
E Ayroldi, O Zollo, A Macchiarulo, B Di Marco, C Marchetti, C Riccardi
Molecular and cellular biology, 2002
Modeling of poly (ADP-ribose) polymerase (PARP) inhibitors. Docking of ligands and quantitative structure− activity relationship analysis
G Costantino, A Macchiarulo, E Camaioni, R Pellicciari
Journal of medicinal chemistry 44 (23), 3786-3794, 2001
Glucocorticoid-induced leucine zipper (GILZ)/NF-κB interaction: role of GILZ homo-dimerization and C-terminal domain
BD Marco, M Massetti, S Bruscoli, A Macchiarulo, RD Virgilio, E Velardi, ...
Nucleic acids research 35 (2), 517-528, 2007
1, 4-Benzothiazine and 1, 4-benzoxazine imidazole derivatives with antifungal activity: a docking study
A Macchiarulo, G Costantino, D Fringuelli, A Vecchiarelli, F Schiaffella, ...
Bioorganic & medicinal chemistry 10 (11), 3415-3423, 2002
Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2, 3-dioxygenase (IDO), a novel target in cancer disease
A Macchiarulo, E Camaioni, R Nuti, R Pellicciari
Amino acids 37, 219-229, 2009
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23-and 6, 23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein …
R Pellicciari, H Sato, A Gioiello, G Costantino, A Macchiarulo, ...
Journal of medicinal chemistry 50 (18), 4265-4268, 2007
Poly (ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure
L Formentini, A Macchiarulo, G Cipriani, E Camaioni, E Rapizzi, ...
Journal of Biological Chemistry 284 (26), 17668-17676, 2009
Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new …
C Carta, S Moretti, L Passeri, F Barbi, N Avenia, A Cavaliere, M Monacelli, ...
Clinical Endocrinology 64 (1), 105-109, 2006
Targeting glucocorticoid side effects: selective glucocorticoid receptor modulator or glucocorticoid‐induced leucine zipper? A perspective
E Ayroldi, A Macchiarulo, C Riccardi
The FASEB Journal 28 (12), 5055-5070, 2014
Ligand selectivity and competition between enzymes in silico
A Macchiarulo, I Nobeli, JM Thornton
Nature biotechnology 22 (8), 1039-1045, 2004
PARP inhibitors: polypharmacology versus selective inhibition
T Ekblad, E Camaioni, H Schüler, A Macchiarulo
The FEBS journal 280 (15), 3563-3575, 2013
Synthesis, docking studies and anti-inflammatory activity of 4, 5, 6, 7-tetrahydro-2H-indazole derivatives
O Rosati, M Curini, MC Marcotullio, A Macchiarulo, M Perfumi, L Mattioli, ...
Bioorganic & medicinal chemistry 15 (10), 3463-3473, 2007
Role of TGR5 (GPBAR1) in liver disease
V Keitel, D Häussinger
Seminars in liver disease 38 (04), 333-339, 2018
Indoleamine 2, 3-dioxygenase 1 (IDO1) is up-regulated in thyroid carcinoma and drives the development of an immunosuppressant tumor microenvironment
S Moretti, E Menicali, P Voce, S Morelli, S Cantarelli, M Sponziello, ...
The Journal of Clinical Endocrinology & Metabolism 99 (5), E832-E840, 2014
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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