| α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling G Chen, Y Liu, R Goetz, L Fu, S Jayaraman, MC Hu, OW Moe, G Liang, ... Nature 553 (7689), 461-466, 2018 | 404 | 2018 |
| Structure of a CENP-A–histone H4 heterodimer in complex with chaperone HJURP H Hu, Y Liu, M Wang, J Fang, H Huang, N Yang, Y Li, J Wang, X Yao, ... Genes & development 25 (9), 901-906, 2011 | 201 | 2011 |
| Uncoupling the mitogenic and metabolic functions of FGF1 by tuning FGF1-FGF receptor dimer stability Z Huang, Y Tan, J Gu, Y Liu, L Song, J Niu, L Zhao, L Srinivasan, Q Lin, ... Cell reports 20 (7), 1717-1728, 2017 | 87 | 2017 |
| Congenital hypogonadotropic hypogonadism with split hand/foot malformation: a clinical entity with a high frequency of FGFR1 mutations C Villanueva, E Jacobson-Dickman, C Xu, S Manouvrier, AA Dwyer, ... Genetics in Medicine 17 (8), 651-659, 2015 | 76 | 2015 |
| Molecular mechanics-driven graph neural network with multiplex graph for molecular structures S Zhang, Y Liu, L Xie arXiv preprint arXiv:2011.07457, 2020 | 55 | 2020 |
| DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors Z Huang, L Tan, H Wang, Y Liu, S Blais, J Deng, TA Neubert, NS Gray, ... ACS chemical biology 10 (1), 299-309, 2015 | 52 | 2015 |
| Regulation of receptor binding specificity of FGF9 by an autoinhibitory homodimerization Y Liu, J Ma, A Beenken, L Srinivasan, AV Eliseenkova, M Mohammadi Structure 25 (9), 1325-1336. e3, 2017 | 29 | 2017 |
| COVID-19 multi-targeted drug repurposing using few-shot learning Y Liu, Y Wu, X Shen, L Xie Frontiers in Bioinformatics 1, 693177, 2021 | 26 | 2021 |
| Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases L Zhao, J Niu, H Lin, J Zhao, Y Liu, Z Song, C Xiang, X Wang, Y Yang, ... EBioMedicine 48, 462-477, 2019 | 20 | 2019 |
| Preliminary crystallographic analysis of the RNA-binding domain of HuR and its poly (U)-binding properties H Wang, H Li, H Shi, Y Liu, H Liu, H Zhao, L Niu, M Teng, X Li Acta Crystallographica Section F: Structural Biology and Crystallization …, 2011 | 12 | 2011 |
| End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins T Cai, L Xie, S Zhang, M Chen, D He, A Badkul, Y Liu, HK Namballa, ... PLOS Computational Biology 19 (1), e1010851, 2023 | 8 | 2023 |
| Exploration of chemical space with partial labeled noisy student self-training and self-supervised graph embedding Y Liu, H Lim, L Xie BMC bioinformatics 23 (Suppl 3), 158, 2022 | 8 | 2022 |
| Exploration of dark chemical genomics space via portal learning: applied to targeting the undruggable genome and covid-19 anti-infective polypharmacology T Cai, L Xie, M Chen, Y Liu, D He, S Zhang, C Mura, PE Bourne, L Xie Research Square, 2021 | 4 | 2021 |
| DeepREAL: A Deep Learning Powered Multi-scale Modeling Framework Towards Predicting Out-of-distribution Receptor Activity of Ligand Binding T Cai, KA Abbu, Y Liu, L Xie bioRxiv, 2021.09. 12.460001, 2021 | 1 | 2021 |
| Reinforcement Learning for Personalized Drug Discovery and Design for Complex Diseases: A Systems Pharmacology Perspective RK Tan, Y Liu, L Xie arXiv preprint arXiv:2201.08894, 2022 | | 2022 |
