Constantinos Koumenis
Constantinos Koumenis
Department of Radiation Oncology, University of Pennsylvania School of Medicine
Email verificata su - Home page
Citata da
Citata da
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
autophagy 12 (1), 1-222, 2016
ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
M Bi, C Naczki, M Koritzinsky, D Fels, J Blais, N Hu, H Harding, I Novoa, ...
The EMBO journal 24 (19), 3470-3481, 2005
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α
C Koumenis, C Naczki, M Koritzinsky, S Rastani, A Diehl, N Sonenberg, ...
Molecular and cellular biology 22 (21), 7405-7416, 2002
The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
J Ye, M Kumanova, LS Hart, K Sloane, H Zhang, DN De Panis, ...
The EMBO journal 29 (12), 2082-2096, 2010
Activating transcription factor 4 is translationally regulated by hypoxic stress
JD Blais, V Filipenko, M Bi, HP Harding, D Ron, C Koumenis, BG Wouters, ...
Molecular and cellular biology 24 (17), 7469-7482, 2004
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
C Koumenis, R Alarcon, E Hammond, P Sutphin, W Hoffman, M Murphy, ...
Molecular and cellular biology 21 (4), 1297-1310, 2001
The PERK/eIF2α/ATF4 module of the UPR in hypoxia resistance and tumor growth
DR Fels, C Koumenis
Cancer biology & therapy 5 (7), 723-728, 2006
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
M Koritzinsky, MG Magagnin, T van den Beucken, R Seigneuric, ...
The EMBO journal 25 (5), 1114-1125, 2006
Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma
XH Ma, SF Piao, S Dey, Q Mcafee, G Karakousis, J Villanueva, LS Hart, ...
The Journal of clinical investigation 124 (3), 1406-1417, 2014
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
JD Blais, CL Addison, R Edge, T Falls, H Zhao, K Wary, C Koumenis, ...
Molecular and cellular biology 26 (24), 9517-9532, 2006
ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth
LS Hart, JT Cunningham, T Datta, S Dey, F Tameire, SL Lehman, B Qiu, ...
The Journal of clinical investigation 122 (12), 4621-4634, 2012
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β
LK Qu, S Huang, D Baltzis, AM Rivas-Estilla, O Pluquet, M Hatzoglou, ...
Genes & development 18 (3), 261-277, 2004
ER stress, hypoxia tolerance and tumor progression
C Koumenis
Current molecular medicine 6 (1), 55-69, 2006
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
E Bobrovnikova-Marjon, C Grigoriadou, D Pytel, F Zhang, J Ye, ...
Oncogene 29 (27), 3881-3895, 2010
“Translating” Tumor Hypoxia: Unfolded Protein Response (UPR)–Dependent and UPR-Independent Pathways
C Koumenis, BG Wouters
Molecular Cancer Research 4 (7), 423-436, 2006
Control of the hypoxic response through regulation of mRNA translation
BG Wouters, T van den Beucken, MG Magagnin, M Koritzinsky, D Fels, ...
Seminars in cell & developmental biology 16 (4-5), 487-501, 2005
The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen …
P Javvadi, AT Segan, SW Tuttle, C Koumenis
Molecular pharmacology 73 (5), 1491-1501, 2008
Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
R Alarcón, C Koumenis, RK Geyer, CG Maki, AJ Giaccia
Cancer research 59 (24), 6046-6051, 1999
Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells
JL Little, FB Wheeler, DR Fels, C Koumenis, SJ Kridel
Cancer research 67 (3), 1262-1269, 2007
miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner
NS Chitnis, D Pytel, E Bobrovnikova-Marjon, D Pant, H Zheng, NL Maas, ...
Molecular cell 48 (3), 353-364, 2012
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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