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Petra Lukacik
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Structural insight into the biogenesis of β-barrel membrane proteins
N Noinaj, AJ Kuszak, JC Gumbart, P Lukacik, H Chang, NC Easley, ...
Nature 501 (7467), 385-390, 2013
4532013
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
A Douangamath, D Fearon, P Gehrtz, T Krojer, P Lukacik, CD Owen, ...
Nature communications 11 (1), 5047, 2020
4302020
Structure and function of human 17β-hydroxysteroid dehydrogenases
P Lukacik, KL Kavanagh, U Oppermann
Molecular and cellular endocrinology 248 (1-2), 61-71, 2006
2362006
Autotransporter structure reveals intra-barrel cleavage followed by conformational changes
TJ Barnard, N Dautin, P Lukacik, HD Bernstein, SK Buchanan
Nature structural & molecular biology 14 (12), 1214-1220, 2007
2022007
Structural engineering of a phage lysin that targets Gram-negative pathogens
P Lukacik, TJ Barnard, PW Keller, KS Chaturvedi, N Seddiki, JW Fairman, ...
Proceedings of the National Academy of Sciences 109 (25), 9857-9862, 2012
1692012
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ...
Cell Stem Cell 29 (2), 217-231. e8, 2022
1652022
Complement regulation at the molecular level: the structure of decay-accelerating factor
P Lukacik, P Roversi, J White, D Esser, GP Smith, J Billington, ...
Proceedings of the National Academy of Sciences 101 (5), 1279-1284, 2004
1442004
Structure of colicin I receptor bound to the R‐domain of colicin Ia: implications for protein import
SK Buchanan, P Lukacik, S Grizot, R Ghirlando, MMU Ali, TJ Barnard, ...
The EMBO journal 26 (10), 2594-2604, 2007
1252007
Structural insights into Ail-mediated adhesion in Yersinia pestis
S Yamashita, P Lukacik, TJ Barnard, N Noinaj, S Felek, TM Tsang, ...
Structure 19 (11), 1672-1682, 2011
1082011
Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity
P Lukacik, B Keller, G Bunkoczi, K Kavanagh, W Hwa Lee, J Adamski, ...
Biochemical Journal 402 (3), 419-427, 2007
1042007
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-β-hydroxybutyrate dehydrogenase
K Guo, P Lukacik, E Papagrigoriou, M Meier, WH Lee, J Adamski, ...
Journal of biological chemistry 281 (15), 10291-10297, 2006
812006
SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation
X Wu, P Lukacik, KL Kavanagh, U Oppermann
Molecular and cellular endocrinology 265, 71-76, 2007
692007
Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding
HTH Chan, MA Moesser, RK Walters, TR Malla, RM Twidale, T John, ...
Chemical science 12 (41), 13686-13703, 2021
602021
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor
D Zaidman, P Gehrtz, M Filep, D Fearon, R Gabizon, A Douangamath, ...
Cell chemical biology 28 (12), 1795-1806. e5, 2021
592021
Streptococcus pneumoniae NanC: structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor
CD Owen, P Lukacik, JA Potter, O Sleator, GL Taylor, MA Walsh
Journal of Biological Chemistry 290 (46), 27736-27748, 2015
572015
Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint
P Roversi, L Marti, AT Caputo, DS Alonzi, JC Hill, KC Dent, A Kumar, ...
Proceedings of the National Academy of Sciences 114 (32), 8544-8549, 2017
552017
COVID moonshot: open science discovery of SARS-CoV-2 main protease inhibitors by combining crowdsourcing, high-throughput experiments, computational simulations, and machine …
H Achdout, A Aimon, E Bar-David, GM Morris
BioRxiv, 2020
532020
Biological activity, membrane‐targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli
J White, P Lukacik, D Esser, M Steward, N Giddings, JR Bright, ...
Protein science 13 (9), 2406-2415, 2004
482004
Using a bacteriocin structure to engineer a phage lysin that targets Yersinia pestis
P Lukacik, TJ Barnard, SK Buchanan
Biochemical Society Transactions 40 (6), 1503-1506, 2012
462012
Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M pro inhibitors
TR Malla, A Tumber, T John, L Brewitz, C Strain-Damerell, CD Owen, ...
Chemical Communications 57 (12), 1430-1433, 2021
422021
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