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André Lechel
André Lechel
Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany
Email verificata su uni-ulm.de
Titolo
Citata da
Citata da
Anno
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
AR Choudhury, Z Ju, MW Djojosubroto, A Schienke, A Lechel, ...
Nature genetics 39 (1), 99-105, 2007
5052007
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage
J Wang, Q Sun, Y Morita, H Jiang, A Groß, A Lechel, K Hildner, ...
Cell 148 (5), 1001-1014, 2012
3742012
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
S Schwitalla, PK Ziegler, D Horst, V Becker, I Kerle, Y Begus-Nahrmann, ...
Cancer cell 23 (1), 93-106, 2013
2962013
p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer
DF Tschaharganeh, W Xue, DF Calvisi, M Evert, TV Michurina, LE Dow, ...
Cell 158 (3), 579-592, 2014
2442014
Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling
M Hohwieler, A Illing, PC Hermann, T Mayer, M Stockmann, L Perkhofer, ...
Gut 66 (3), 473-486, 2017
2182017
Telomerase gene mutations are associated with cirrhosis formation
D Hartmann, U Srivastava, M Thaler, KN Kleinhans, G N'kontchou, ...
Hepatology 53 (5), 1608-1617, 2011
1932011
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice
S Schaetzlein, NR Kodandaramireddy, Z Ju, A Lechel, A Stepczynska, ...
Cell 130 (5), 863-877, 2007
1742007
Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis
RR Plentz, YN Park, A Lechel, H Kim, F Nellessen, BHE Langkopf, ...
Hepatology 45 (4), 968-976, 2007
1652007
Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition
R Russell, L Perkhofer, S Liebau, Q Lin, A Lechel, FM Feld, E Hessmann, ...
Nature communications 6 (1), 7677, 2015
1482015
Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri
N Hartmann, K Reichwald, A Lechel, M Graf, J Kirschner, A Dorn, ...
Mechanisms of ageing and development 130 (5), 290-296, 2009
1402009
Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals
S Schwoerer, F Becker, C Feller, AH Baig, U Koeber, H Henze, JM Kraus, ...
Nature 540 (7633), 428-432, 2016
1242016
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
Y Begus-Nahrmann, A Lechel, AC Obenauf, K Nalapareddy, E Peit, ...
Nature genetics 41 (10), 1138-1143, 2009
1242009
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo
A Lechel, A Satyanarayana, Z Ju, RR Plentz, S Schaetzlein, C Rudolph, ...
EMBO reports 6 (3), 275-281, 2005
1242005
Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation
SF Katz, A Lechel, AC Obenauf, Y Begus–Nahrmann, JM Kraus, ...
Gastroenterology 142 (5), 1229-1239. e3, 2012
1112012
ATM deficiency generating genomic instability sensitizes pancreatic ductal adenocarcinoma cells to therapy-induced DNA damage
L Perkhofer, A Schmitt, MC Romero Carrasco, M Ihle, S Hampp, ...
Cancer research 77 (20), 5576-5590, 2017
1032017
Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage
S Tao, D Tang, Y Morita, T Sperka, O Omrani, A Lechel, V Sakk, J Kraus, ...
The EMBO journal 34 (5), 624-640, 2015
942015
Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease
A Lechel, H Holstege, Y Begus, A Schienke, K Kamino, U Lehmann, ...
Gastroenterology 132 (4), 1465-1475, 2007
862007
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway
A von Witzleben, LT Goerttler, R Marienfeld, H Barth, A Lechel, K Mellert, ...
Cancer research 75 (18), 3823-3831, 2015
852015
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis
Y Begus-Nahrmann, D Hartmann, J Kraus, P Eshraghi, A Scheffold, ...
The Journal of clinical investigation 122 (6), 2283-2288, 2021
792021
Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction
T Sperka, Z Song, Y Morita, K Nalapareddy, LM Guachalla, A Lechel, ...
Nature cell biology 14 (1), 73-79, 2012
762012
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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