| Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase L Tomei, S Altamura, L Bartholomew, A Biroccio, A Ceccacci, L Pacini, ... Journal of Virology 77 (24), 13225-13231, 2003 | 240 | 2003 |
| Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site S Di Marco, C Volpari, L Tomei, S Altamura, S Harper, F Narjes, U Koch, ... Journal of Biological Chemistry 280 (33), 29765-29770, 2005 | 205 | 2005 |
| A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease F Narjes, KF Koehler, U Koch, B Gerlach, S Colarusso, C Steinkühler, ... Bioorganic & medicinal chemistry letters 12 (4), 701-704, 2002 | 196 | 2002 |
| A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates M Taliani, E Bianchi, F Narjes, M Fossatelli, A Urbani, C Steinkühler, ... Analytical biochemistry 240 (1), 60-67, 1996 | 166 | 1996 |
| In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor C Trozzi, L Bartholomew, A Ceccacci, G Biasiol, L Pacini, S Altamura, ... Journal of Virology 77 (6), 3669-3679, 2003 | 159 | 2003 |
| 2-(2-Thienyl)-5, 6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis U Koch, B Attenni, S Malancona, S Colarusso, I Conte, M Di Filippo, ... Journal of Medicinal Chemistry 49 (5), 1693-1705, 2006 | 151 | 2006 |
| Inhibition of the hepatitis C virus NS3/4A protease: the crystal structures of two protease-inhibitor complexes S Di Marco, M Rizzi, C Volpari, MA Walsh, F Narjes, S Colarusso, ... Journal of Biological Chemistry 275 (10), 7152-7157, 2000 | 148 | 2000 |
| Substrate specificity of the hepatitis C virus serine protease NS3 A Urbani, E Bianchi, F Narjes, A Tramontano, R De Francesco, ... Journal of Biological Chemistry 272 (14), 9204-9209, 1997 | 142 | 1997 |
| Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase U Koch, F Narjes Current Topics in Medicinal Chemistry 7 (13), 1302-1329, 2007 | 140 | 2007 |
| Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase S Harper, S Avolio, B Pacini, M Di Filippo, S Altamura, L Tomei, ... Journal of Medicinal Chemistry 48 (14), 4547-4557, 2005 | 131 | 2005 |
| Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein M Pallaoro, A Lahm, G Biasiol, M Brunetti, C Nardella, L Orsatti, F Bonelli, ... Journal of virology 75 (20), 9939-9946, 2001 | 120 | 2001 |
| Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase S Harper, B Pacini, S Avolio, M Di Filippo, G Migliaccio, R Laufer, ... Journal of Medicinal Chemistry 48 (5), 1314-1317, 2005 | 116 | 2005 |
| Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection F Narjes, C Gardelli, M Donghi, B Attenni, PL Durette US Patent 8,071,568, 2011 | 113 | 2011 |
| Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain G Barbato, DO Cicero, F Cordier, F Narjes, B Gerlach, S Sambucini, ... The EMBO Journal, 2000 | 110 | 2000 |
| Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection M MacCoss, DB Olsen, M Donghi, C Gardelli, S Harper, M Meppen, ... US Patent 7,879,815, 2011 | 109 | 2011 |
| Bacteriohopanetetrol from chemical degradation of an oil shale kerogen B Mycke, F Narjes, W Michaelis Nature 326 (6109), 179-81, 1987 | 102 | 1987 |
| Hepatitis C virus serine protease inhibitors: current progress and future challenges C Steinkulher, U Kock, F Narjes, VG Matassa Current medicinal chemistry 8 (8), 919-932, 2001 | 92 | 2001 |
| α-Ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease F Narjes, M Brunetti, S Colarusso, B Gerlach, U Koch, G Biasiol, D Fattori, ... Biochemistry 39 (7), 1849-1861, 2000 | 92 | 2000 |
| Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection M Meppen, F Narjes, B Pacini, C Gardelli, PL Durette US Patent 8,148,349, 2012 | 91 | 2012 |
| Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a … F Narjes, B Crescenzi, M Ferrara, J Habermann, S Colarusso, ... Journal of medicinal chemistry 54 (1), 289-301, 2011 | 71 | 2011 |
Uwe KochLead-Discovery-CenterEmail verificata su lead-discovery.de
