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R Wang, Y Lu, S Wang
Journal of medicinal chemistry 46 (12), 2287-2303, 2003
|Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition|
S Shangary, D Qin, D McEachern, M Liu, RS Miller, S Qiu, ...
Proceedings of the National Academy of Sciences 105 (10), 3933-3938, 2008
|The PDBbind database: Collection of binding affinities for protein− ligand complexes with known three-dimensional structures|
R Wang, X Fang, Y Lu, S Wang
Journal of medicinal chemistry 47 (12), 2977-2980, 2004
|Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2− p53 interaction|
K Ding, Y Lu, Z Nikolovska-Coleska, G Wang, S Qiu, S Shangary, W Gao, ...
Journal of medicinal chemistry 49 (12), 3432-3435, 2006
|Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer|
IA Asangani, VL Dommeti, X Wang, R Malik, M Cieslik, R Yang, ...
Nature 510 (7504), 278-282, 2014
|Structure-based design of potent non-peptide MDM2 inhibitors|
K Ding, Y Lu, Z Nikolovska-Coleska, S Qiu, Y Ding, W Gao, J Stuckey, ...
Journal of the American Chemical Society 127 (29), 10130-10131, 2005
|Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy|
S Shangary, S Wang
Annual review of pharmacology and toxicology 49, 223-241, 2009
|A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells|
H Song, R Wang, S Wang, J Lin
Proceedings of the National Academy of Sciences 102 (13), 4700-4705, 2005
|The PDBbind database: methodologies and updates|
R Wang, X Fang, Y Lu, CY Yang, S Wang
Journal of medicinal chemistry 48 (12), 4111-4119, 2005
|Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization|
Z Nikolovska-Coleska, R Wang, X Fang, H Pan, Y Tomita, P Li, PP Roller, ...
Analytical biochemistry 332 (2), 261-273, 2004
|Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three …|
Z Nikolovska-Coleska, L Xu, Z Hu, Y Tomita, P Li, PP Roller, R Wang, ...
Journal of medicinal chemistry 47 (10), 2430-2440, 2004
|Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening|
IJ Enyedy, Y Ling, K Nacro, Y Tomita, X Wu, Y Cao, R Guo, B Li, X Zhu, ...
Journal of medicinal chemistry 44 (25), 4313-4324, 2001
|Coumarin-Based Inhibitors of HIV Integrase|
H Zhao, N Neamati, H Hong, A Mazumder, S Wang, S Sunder, GWA Milne, ...
Journal of medicinal chemistry 40 (2), 242-249, 1997
|Small-molecule inhibitors of the MDM2–p53 protein–protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment: miniperspective|
Y Zhao, A Aguilar, D Bernard, S Wang
Journal of medicinal chemistry 58 (3), 1038-1052, 2015
|Targeting the MDM2-p53 interaction for cancer therapy|
S Shangary, S Wang
Clinical Cancer Research 14 (17), 5318-5324, 2008
|Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins|
G Wang, Z Nikolovska-Coleska, CY Yang, R Wang, G Tang, J Guo, ...
Journal of medicinal chemistry 49 (21), 6139-6142, 2006
|Computer automated log P calculations based on an extended group contribution approach|
G Klopman, JY Li, S Wang, M Dimayuga
Journal of Chemical Information and Computer Sciences 34 (4), 752-781, 1994
|How does consensus scoring work for virtual library screening? An idealized computer experiment|
R Wang, S Wang
Journal of Chemical Information and Computer Sciences 41 (5), 1422-1426, 2001
|Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching|
N Neamati, H Hong, A Mazumder, S Wang, S Sunder, MC Nicklaus, ...
Journal of medicinal chemistry 40 (6), 942-951, 1997
|An extensive test of 14 scoring functions using the PDBbind refined set of 800 protein− ligand complexes|
R Wang, Y Lu, X Fang, S Wang
Journal of chemical information and computer sciences 44 (6), 2114-2125, 2004