| The use of spirocyclic scaffolds in drug discovery Y Zheng, CM Tice, SB Singh Bioorganic & Medicinal Chemistry Letters 24 (16), 3673-3682, 2014 | 878 | 2014 |
| Solution conformation of the major adduct between the carcinogen (+)-anti-benzo [a] pyrene diol epoxide and DNA. M Cosman, C De Los Santos, R Fiala, BE Hingerty, SB Singh, V Ibanez, ... Proceedings of the National Academy of Sciences 89 (5), 1914-1918, 1992 | 354 | 1992 |
| Text influenced molecular indexing system and computer-implemented and/or computer-assisted method for same RD Hull, EM Fluder Jr, SB Singh US Patent 6,542,903, 2003 | 245 | 2003 |
| A model for predicting likely sites of CYP3A4-mediated metabolism on drug-like molecules SB Singh, LQ Shen, MJ Walker, RP Sheridan Journal of medicinal chemistry 46 (8), 1330-1336, 2003 | 187 | 2003 |
| Protocols for bridging the peptide to nonpeptide gap in topological similarity searches RP Sheridan, SB Singh, EM Fluder, SK Kearsley Journal of chemical information and computer sciences 41 (5), 1395-1406, 2001 | 167 | 2001 |
| Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase RGK Donald, J Allocco, SB Singh, B Nare, SP Salowe, J Wiltsie, ... Eukaryotic cell 1 (3), 317-328, 2002 | 161 | 2002 |
| Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer’s disease J Yuan, S Venkatraman, Y Zheng, BM McKeever, LW Dillard, SB Singh Journal of medicinal chemistry 56 (11), 4156-4180, 2013 | 149 | 2013 |
| Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes K Sauer, J Liou, SB Singh, D Yablonski, A Weiss, RM Perlmutter Journal of Biological Chemistry 276 (48), 45207-45216, 2001 | 142 | 2001 |
| SAR of 3, 4-Dihydropyrido [3, 2-d] pyrimidone p38 Inhibitors L Liu, JE Stelmach, SR Natarajan, MH Chen, SB Singh, CD Schwartz, ... Bioorganic & medicinal chemistry letters 13 (22), 3979-3982, 2003 | 138 | 2003 |
| Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity G Scapin, SB Patel, C Chung, JP Varnerin, SD Edmondson, ... Biochemistry 43 (20), 6091-6100, 2004 | 137 | 2004 |
| Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase JE Stelmach, L Liu, SB Patel, JV Pivnichny, G Scapin, S Singh, ... Bioorganic & medicinal chemistry letters 13 (2), 277-280, 2003 | 105 | 2003 |
| Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin T Biftu, G Scapin, S Singh, D Feng, JW Becker, G Eiermann, H He, ... Bioorganic & medicinal chemistry letters 17 (12), 3384-3387, 2007 | 84 | 2007 |
| Structure and stereochemistry of rediocide A, a highly modified daphnane from Trigonostemon reidioides exhibiting potent insecticidal activity H Jayasuriya, DL Zink, SB Singh, RP Borris, W Nanakorn, HT Beck, ... Journal of the American Chemical Society 122 (20), 4998-4999, 2000 | 72 | 2000 |
| Structures of the (+)- and (-)-trans-7,8-Dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene Adducts to Guanine-N2 in a Duplex Dodecamer SB Singh, BE Hingerty, UC Singh, JP Greenberg, NE Geacintov, S Broyde Cancer research 51 (13), 3482-3492, 1991 | 69 | 1991 |
| p38 MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3, 4-dihydropyrido [3, 2-d] pyrimidone scaffold SR Natarajan, DD Wisnoski, SB Singh, JE Stelmach, EA O'Neill, ... Bioorganic & medicinal chemistry letters 13 (2), 273-276, 2003 | 65 | 2003 |
| (3R)-4-[(3R)-3-Amino-4-(2, 4, 5-trifluorophenyl) butanoyl]-3-(2, 2, 2-trifluoroethyl)-1, 4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of … T Biftu, D Feng, X Qian, GB Liang, G Kieczykowski, G Eiermann, H He, ... Bioorganic & Medicinal Chemistry Letters 17 (1), 49-52, 2007 | 61 | 2007 |
| Identification of Phe313 of the Gonadotropin-Releasing Hormone (GnRH) Receptor as a Site Critical for the Binding of Nonpeptide GnRH Antagonists J Cui, RG Smith, GR Mount, JL Lo, J Yu, TF Walsh, SB Singh, RJ DeVita, ... Molecular Endocrinology 14 (5), 671-681, 2000 | 59 | 2000 |
| Latent semantic structure indexing (LaSSI) for defining chemical similarity RD Hull, SB Singh, RB Nachbar, RP Sheridan, SK Kearsley, EM Fluder Journal of medicinal chemistry 44 (8), 1177-1184, 2001 | 57 | 2001 |
| Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones SL Colletti, JL Frie, EC Dixon, SB Singh, BK Choi, G Scapin, ... Journal of medicinal chemistry 46 (3), 349-352, 2003 | 56 | 2003 |
| Conformational control in structure-based drug design Y Zheng, CM Tice, SB Singh Bioorganic & Medicinal Chemistry Letters 27 (13), 2825-2837, 2017 | 53 | 2017 |
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