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Yi-Lynn Liang
Yi-Lynn Liang
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Verified email at confotherapeutics.com
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Cited by
Year
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
YL Liang, M Khoshouei, M Radjainia, Y Zhang, A Glukhova, J Tarrasch, ...
Nature 546 (7656), 118-123, 2017
4812017
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
CJ Draper-Joyce, M Khoshouei, DM Thal, YL Liang, ATN Nguyen, ...
Nature 558 (7711), 559-563, 2018
3202018
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
YL Liang, M Khoshouei, A Glukhova, SGB Furness, P Zhao, L Clydesdale, ...
Nature 555 (7694), 121-125, 2018
2982018
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
YL Liang, M Khoshouei, G Deganutti, A Glukhova, C Koole, TS Peat, ...
Nature 561 (7724), 492-497, 2018
2302018
Activation of the GLP-1 receptor by a non-peptidic agonist
P Zhao, YL Liang, MJ Belousoff, G Deganutti, MM Fletcher, FS Willard, ...
Nature 577 (7790), 432-436, 2020
1312020
Ligand-dependent modulation of G protein conformation alters drug efficacy
SGB Furness, YL Liang, CJ Nowell, ML Halls, PJ Wookey, E Dal Maso, ...
Cell 167 (3), 739-749. e11, 2016
1262016
Differential GLP-1R binding and activation by peptide and non-peptide agonists
X Zhang, MJ Belousoff, P Zhao, AJ Kooistra, TT Truong, SY Ang, ...
Molecular Cell 80 (3), 485-500. e7, 2020
1202020
Toward a structural understanding of class B GPCR peptide binding and activation
YL Liang, MJ Belousoff, P Zhao, C Koole, MM Fletcher, TT Truong, ...
Molecular cell 77 (3), 656-668. e5, 2020
952020
Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination
YL Liang, P Zhao, C Draper-Joyce, JA Baltos, A Glukhova, TT Truong, ...
ACS pharmacology & translational science 1 (1), 12-20, 2018
922018
Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity …
YL Liang, MJ Belousoff, MM Fletcher, X Zhang, M Khoshouei, G Deganutti, ...
ACS pharmacology & translational science 3 (2), 263-284, 2020
742020
Structure and dynamics of the CGRP receptor in apo and peptide-bound forms
TM Josephs, MJ Belousoff, YL Liang, SJ Piper, J Cao, DJ Garama, ...
Science 372 (6538), eabf7258, 2021
632021
Recent advances in the determination of G protein-coupled receptor structures
DM Thal, Z Vuckovic, CJ Draper-Joyce, YL Liang, A Glukhova, ...
Current opinion in structural biology 51, 28-34, 2018
632018
Structure and dynamics of the active Gs-coupled human secretin receptor
M Dong, G Deganutti, SJ Piper, YL Liang, M Khoshouei, MJ Belousoff, ...
Nature communications 11 (1), 4137, 2020
492020
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism
S Lei, L Clydesdale, A Dai, X Cai, Y Feng, D Yang, YL Liang, C Koole, ...
Journal of Biological Chemistry 293 (24), 9370-9387, 2018
492018
High-throughput production and structural characterization of libraries of self-assembly lipidic cubic phase materials
C Darmanin, CE Conn, J Newman, X Mulet, SA Seabrook, YL Liang, ...
ACS combinatorial science 14 (4), 247-252, 2012
462012
The molecular control of calcitonin receptor signaling
E Dal Maso, A Glukhova, Y Zhu, J Garcia-Nafria, CG Tate, S Atanasio, ...
ACS Pharmacology & Translational Science 2 (1), 31-51, 2019
442019
Routine sub-2.5 Å cryo-EM structure determination of GPCRs
R Danev, M Belousoff, YL Liang, X Zhang, F Eisenstein, D Wootten, ...
Nature Communications 12 (1), 4333, 2021
422021
Structural perspective of class B1 GPCR signaling
Z Cong, YL Liang, Q Zhou, S Darbalaei, F Zhao, W Feng, L Zhao, HE Xu, ...
Trends in Pharmacological Sciences 43 (4), 321-334, 2022
402022
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
G Deganutti, YL Liang, X Zhang, M Khoshouei, L Clydesdale, ...
Nature Communications 13 (1), 92, 2022
392022
A structural basis for amylin receptor phenotype
J Cao, MJ Belousoff, YL Liang, RM Johnson, TM Josephs, MM Fletcher, ...
Science 375 (6587), eabm9609, 2022
342022
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