Yuichiro Higashimoto
Yuichiro Higashimoto
Department of Chemistry, Kurume University School of Medicine
Verified email at
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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
M Pearson, R Carbone, C Sebastiani, M Cioce, M Fagioli, S Saito, ...
Nature 406 (6792), 207-210, 2000
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
G D'Orazi, B Cecchinelli, T Bruno, I Manni, Y Higashimoto, S Saito, ...
Nature cell biology 4 (1), 11-19, 2002
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
DV Bulavin, Y Higashimoto, IJ Popoff, WA Gaarde, V Basrur, O Potapova, ...
Nature 411 (6833), 102-107, 2001
MDM2–HDAC1‐mediated deacetylation of p53 is required for its degradation
A Ito, Y Kawaguchi, CH Lai, JJ Kovacs, Y Higashimoto, E Appella, TP Yao
The EMBO journal, 2002
ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation∗
S Saito, AA Goodarzi, Y Higashimoto, Y Noda, SP Lees-Miller, E Appella, ...
Journal of Biological Chemistry 277 (15), 12491-12494, 2002
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
LJ Hofseth, S Saito, SP Hussain, MG Espey, KM Miranda, Y Araki, ...
Proceedings of the national academy of sciences 100 (1), 143-148, 2003
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase: Effect on Mdm2 binding
K Sakaguchi, S Saito, Y Higashimoto, S Roy, CW Anderson, E Appella
Journal of Biological Chemistry 275 (13), 9278-9283, 2000
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
M Shiseki, M Nagashima, RM Pedeux, M Kitahama-Shiseki, K Miura, ...
Cancer research 63 (10), 2373-2378, 2003
Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene
S Hayashi, Y Omata, H Sakamoto, Y Higashimoto, T Hara, Y Sagara, ...
Gene 336 (2), 241-250, 2004
A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes
B Livingston, C Crimi, M Newman, Y Higashimoto, E Appella, J Sidney, ...
The Journal of Immunology 168 (11), 5499-5506, 2002
A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity
F Fazioli, M Resnati, N Sidenius, Y Higashimoto, E Appella, F Blasi
The EMBO Journal 16 (24), 7279-7286, 1997
Phosphorylation site interdependence of human p53 post-translational modifications in response to stress
S Saito, H Yamaguchi, Y Higashimoto, C Chao, Y Xu, AJ Fornace, ...
Journal of Biological Chemistry 278 (39), 37536-37544, 2003
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry
DV Bulavin, Y Higashimoto, ZN Demidenko, S Meek, P Graves, C Phillips, ...
Nature cell biology 5 (6), 545-551, 2003
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins
V Basrur, F Yang, T Kushimoto, Y Higashimoto, K Yasumoto, J Valencia, ...
Journal of proteome research 2 (1), 69-79, 2003
Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like …
Y Ishibashi, T Matsui, S Maeda, Y Higashimoto, S Yamagishi
Cardiovascular diabetology 12, 1-9, 2013
Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents
Y Higashimoto, S Saito, XH Tong, A Hong, K Sakaguchi, E Appella, ...
Journal of Biological Chemistry 275 (30), 23199-23203, 2000
HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles
DL Doolan, S Southwood, R Chesnut, E Appella, E Gomez, A Richards, ...
The journal of immunology 165 (2), 1123-1137, 2000
A novel secreted protease from Pseudomonas aeruginosa activates NF‐κB through protease‐activated receptors
Y Kida, Y Higashimoto, H Inoue, T Shimizu, K Kuwano
Cellular microbiology 10 (7), 1491-1504, 2008
Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes
CC Wilson, B Palmer, S Southwood, J Sidney, Y Higashimoto, E Appella, ...
Journal of virology 75 (9), 4195-4207, 2001
Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences
JCD Houtman, Y Higashimoto, N Dimasi, S Cho, H Yamaguchi, ...
Biochemistry 43 (14), 4170-4178, 2004
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