Paolo M Comoglio
Paolo M Comoglio
IFOM (FIRC Institute for Molecular Oncology)
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Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.
F Bussolino, MF Di Renzo, M Ziche, E Bocchietto, M Olivero, L Naldini, ...
The Journal of cell biology 119 (3), 629-641, 1992
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
S Pennacchietti, P Michieli, M Galluzzo, M Mazzone, S Giordano, ...
Cancer cell 3 (4), 347-361, 2003
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates
L Tamagnone, S Artigiani, H Chen, Z He, G Ming, H Song, A Chedotal, ...
Cell 99 (1), 71-80, 1999
MET signalling: principles and functions in development, organ regeneration and cancer
L Trusolino, A Bertotti, PM Comoglio
Nature reviews Molecular cell biology 11 (12), 834-848, 2010
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
C Ponzetto, A Bardelli, Z Zhen, F Maina, P dalla Zonca, S Giordano, ...
Cell 77 (2), 261-271, 1994
A molecularly annotated platform of patient-derived xenografts (“xenopatients”) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
A Bertotti, G Migliardi, F Galimi, F Sassi, D Torti, C Isella, D CorÓ, ...
Cancer discovery 1 (6), 508-523, 2011
Drug development of MET inhibitors: targeting oncogene addiction and expedience
PM Comoglio, S Giordano, L Trusolino
Nature reviews Drug discovery 7 (6), 504-516, 2008
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.
L Naldini, E Vigna, RP Narsimhan, G Gaudino, R Zarnegar, ...
Oncogene 6 (4), 501-504, 1991
Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-ofá…
A Sartore-Bianchi, L Trusolino, C Martino, K Bencardino, S Lonardi, ...
The Lancet Oncology 17 (6), 738-746, 2016
Scatter-factor and semaphorin receptors: cell signalling for invasive growth
L Trusolino, PM Comoglio
Nature reviews cancer 2 (4), 289-300, 2002
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
L Naldini, L Tamagnone, E Vigna, M Sachs, G Hartmann, W Birchmeier, ...
The EMBO journal 11 (13), 4825-4833, 1992
Invasive growth: a MET-driven genetic programme for cancer and stem cells
C Boccaccio, PM Comoglio
Nature Reviews Cancer 6 (8), 637-645, 2006
Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells
AJ Ridley, PM Comoglio, A Hall
Molecular and cellular biology, 1995
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
C Boccaccio, M And˛, L Tamagnone, A Bardelli, P Michieli, C Battistini, ...
Nature 391 (6664), 285-288, 1998
Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer
A Bardelli, S Corso, A Bertotti, S Hobor, E Valtorta, G Siravegna, ...
Cancer discovery 3 (6), 658-673, 2013
Expression of the Met/HGF receptor in normal and neoplastic human tissues.
MF Di Renzo, RP Narsimhan, M Olivero, S Bretti, S Giordano, E Medico, ...
Oncogene 6 (11), 1997-2003, 1991
Tyrosine kinase receptor indistinguishable from the c-met protein
S Giordano, C Ponzetto, MFD Renzo, CS Cooper, PM Comoglio
Nature 339 (6220), 155-156, 1989
Plexin A is a neuronal semaphorin receptor that controls axon guidance
ML Winberg, JN Noordermeer, L Tamagnone, PM Comoglio, MK Spriggs, ...
Cell 95 (7), 903-916, 1998
A signaling adapter function for α6β4 integrin in the control of HGF-dependent invasive growth
L Trusolino, A Bertotti, PM Comoglio
Cell 107 (5), 643-654, 2001
The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met
A Petrelli, GF Gilestro, S Lanzardo, PM Comoglio, N Migone, S Giordano
Nature 416 (6877), 187-190, 2002
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