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Benoît Desguin
Benoît Desguin
Email verificata su uclouvain.be
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Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system
B Desguin, P Goffin, E Viaene, M Kleerebezem, V Martin-Diaconescu, ...
Nature communications 5 (1), 3615, 2014
1132014
A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase
B Desguin, T Zhang, P Soumillion, P Hols, J Hu, RP Hausinger
Science 349 (6243), 66-69, 2015
982015
Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria
GP Bienert, B Desguin, F Chaumont, P Hols
Biochemical Journal 454 (3), 559-570, 2013
962013
Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion
B Desguin, P Soumillion, P Hols, RP Hausinger
Proceedings of the National Academy of Sciences 113 (20), 5598-5603, 2016
482016
Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase
B Desguin, M Fellner, O Riant, J Hu, RP Hausinger, P Hols, P Soumillion
Journal of Biological Chemistry 293 (32), 12303-12317, 2018
402018
Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE
M Fellner, B Desguin, RP Hausinger, J Hu
Proceedings of the National Academy of Sciences 114 (34), 9074-9079, 2017
382017
Lactate racemase nickel-pincer cofactor operates by a proton-coupled hydride transfer mechanism
JA Rankin, RC Mauban, M Fellner, B Desguin, J McCracken, J Hu, ...
Biochemistry 57 (23), 3244-3251, 2018
302018
Enantioselective regulation of lactate racemization by LarR in Lactobacillus plantarum
B Desguin, P Goffin, N Bakouche, A Diman, E Viaene, D Dandoy, ...
Journal of bacteriology 197 (1), 219-230, 2015
252015
Unexpected complexity in the lactate racemization system of lactic acid bacteria
B Desguin, P Soumillion, RP Hausinger, P Hols
FEMS Microbiology Reviews 41 (Supp_1), S71-S83, 2017
222017
Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases
B Desguin, J Urdiain-Arraiza, M Da Costa, M Fellner, J Hu, RP Hausinger, ...
Scientific reports 10 (1), 18123, 2020
192020
Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum
M Fellner, JA Rankin, B Desguin, J Hu, RP Hausinger
Biochemistry 57 (38), 5513-5523, 2018
182018
Nickel–pincer nucleotide cofactor
RP Hausinger, B Desguin, M Fellner, JA Rankin, J Hu
Current Opinion in Chemical Biology 47, 18-23, 2018
142018
The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis
JA Rankin, S Chatterjee, Z Tariq, S Lagishetty, B Desguin, J Hu, ...
Proceedings of the National Academy of Sciences 118 (39), e2106202118, 2021
112021
Lactate racemase and its niacin-derived, covalently-tethered, nickel cofactor
B Desguin, P Soumillion, P Hols, J Hu, RP Hausinger
42017
Structural and mutational characterization of a malate racemase from the LarA superfamily
S Gatreddi, J Urdiain-Arraiza, B Desguin, RP Hausinger, J Hu
Biometals 36 (2), 303-313, 2023
32023
Versatile capillary electrophoresis method for the direct chiral separation of aliphatic and aromatic α-hydroxy acids, β-hydroxy acids and polyhydroxy acids using vancomycin as …
J Urdiain-Arraiza, B Desguin
Journal of Chromatography A 1715, 464611, 2024
12024
Lactate Racemization and Beyond
B Desguin
J Bacteriol Parasitol 9 (335), 2, 2018
12018
PBP-A, a cyanobacterial DD-peptidase with high specificity for amidated muropeptides, exhibits pH-dependent promiscuous activity harmful to Escherichia coli
GM Dorrazehi, M Winkle, M Desmet, V Stroobant, G Tanriver, H Degand, ...
2024
PBP-A, a cyanobacterial DD-peptidase with high specificity for amidated muropeptides, imposes a pH-dependent fitness cost in Escherichia coli as a consequence of promiscuous …
GM Dorrazehi, M Winkle, V Stroobant, H Degand, D Evrard, B Desguin, ...
2023
Biosynthesis and functions of the Nickel-pincer nucleotide (NPN)
B Desguin
Novel Enzymes 2023, 2023
2023
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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