Arun K. Shukla
Arun K. Shukla
Associate Professor & EMBO Young Investigator, Intermediate Fellow, Wellcome Trust DBT India
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TitoloCitata daAnno
Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors
E Reiter, S Ahn, AK Shukla, RJ Lefkowitz
Annual review of pharmacology and toxicology 52, 179-197, 2012
Distinct phosphorylation sites on the β2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin
KN Nobles, K Xiao, S Ahn, AK Shukla, CM Lam, S Rajagopal, ...
Sci. Signal. 4 (185), ra51-ra51, 2011
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
AK Shukla, K Xiao, RJ Lefkowitz
Trends in biochemical sciences 36 (9), 457-469, 2011
Functional specialization of β-arrestin interactions revealed by proteomic analysis
K Xiao, DB McClatchy, AK Shukla, Y Zhao, M Chen, SK Shenoy, JR Yates, ...
Proceedings of the National Academy of Sciences 104 (29), 12011-12016, 2007
Visualization of arrestin recruitment by a G-protein-coupled receptor
AK Shukla, GH Westfield, K Xiao, RI Reis, LY Huang, P Tripathi-Shukla, ...
Nature 512 (7513), 218-222, 2014
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
AK Shukla, A Manglik, AC Kruse, K Xiao, RI Reis, WC Tseng, DP Staus, ...
Nature 497 (7447), 137-141, 2013
GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling
ARB Thomsen, B Plouffe, TJ Cahill III, AK Shukla, JT Tarrasch, AM Dosey, ...
Cell 166 (4), 907-919, 2016
β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice
RW Walters, AK Shukla, JJ Kovacs, JD Violin, SM DeWire, CM Lam, ...
The Journal of clinical investigation 119 (5), 1312-1321, 2009
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
AK Shukla, JD Violin, EJ Whalen, D Gesty-Palmer, SK Shenoy, ...
Proceedings of the National Academy of Sciences 105 (29), 9988-9993, 2008
Multiple ligand-specific conformations of the β2-adrenergic receptor
AW Kahsai, K Xiao, S Rajagopal, S Ahn, AK Shukla, J Sun, TG Oas, ...
Nature chemical biology 7 (10), 692, 2011
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
K Xiao, J Sun, J Kim, S Rajagopal, B Zhai, J Villn, W Haas, JJ Kovacs, ...
Proceedings of the National Academy of Sciences 107 (34), 15299-15304, 2010
Methodological advances: the unsung heroes of the GPCR structural revolution
E Ghosh, P Kumari, D Jaiman, AK Shukla
Nature Reviews Molecular Cell Biology 16 (2), 69-81, 2015
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
SK Shenoy, AS Modi, AK Shukla, K Xiao, M Berthouze, S Ahn, ...
Proceedings of the National Academy of Sciences 106 (16), 6650-6655, 2009
β-Arrestin–dependent activation of Ca2+/calmodulin kinase II after β1–adrenergic receptor stimulation
S Mangmool, AK Shukla, HA Rockman
Journal of Cell Biology 189 (3), 573-587, 2010
Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
TJ Cahill, ARB Thomsen, JT Tarrasch, B Plouffe, AH Nguyen, F Yang, ...
Proceedings of the National Academy of Sciences 114 (10), 2562-2567, 2017
Ubiquitination of β-arrestin links seven-transmembrane receptor endocytosis and ERK activation
SK Shenoy, LS Barak, K Xiao, S Ahn, M Berthouze, AK Shukla, LM Luttrell, ...
Journal of Biological Chemistry 282 (40), 29549-29562, 2007
The structure of the neuropeptide bradykinin bound to the human G‐protein coupled receptor bradykinin B2 as determined by solid‐state NMR spectroscopy
JJ Lopez, AK Shukla, C Reinhart, H Schwalbe, H Michel, C Glaubitz
Angewandte Chemie International Edition 47 (9), 1668-1671, 2008
Emerging structural insights into biased GPCR signaling
AK Shukla, G Singh, E Ghosh
Trends in biochemical sciences 39 (12), 594-602, 2014
Functional competence of a partially engaged GPCR–β-arrestin complex
P Kumari, A Srivastava, R Banerjee, E Ghosh, P Gupta, R Ranjan, X Chen, ...
Nature communications 7 (1), 1-16, 2016
Arresting a Transient Receptor Potential (TRP) Channel β-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
AK Shukla, J Kim, S Ahn, K Xiao, SK Shenoy, W Liedtke, RJ Lefkowitz
Journal of Biological Chemistry 285 (39), 30115-30125, 2010
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
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