| Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly (ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic … Y Errami, AS Naura, H Kim, J Ju, Y Suzuki, AH El-Bahrawy, MA Ghonim, ... Journal of Biological Chemistry 288 (5), 3460-3468, 2013 | 84 | 2013 |
| Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer MA Ghonim, SV Ibba, AF Tarhuni, Y Errami, HH Luu, MJ Dean, ... Journal for immunotherapy of cancer 9 (1), 2021 | 49 | 2021 |
| PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4+ T cell function MA Ghonim, K Pyakurel, SV Ibba, AA Al-Khami, J Wang, P Rodriguez, ... Journal of Translational Medicine 13, 1-12, 2015 | 49 | 2015 |
| PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice MA Ghonim, K Pyakurel, SV Ibba, J Wang, P Rodriguez, AA Al-Khami, ... Clinical Science 129 (11), 951-962, 2015 | 39 | 2015 |
| Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target AA Al‐Khami, MA Ghonim, L Del Valle, SV Ibba, L Zheng, K Pyakurel, ... Clinical & Experimental Allergy 47 (9), 1170-1184, 2017 | 37 | 2017 |
| DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4+ T-cell function without causing severe combined immunodeficiency MA Ghonim, K Pyakurel, J Ju, PC Rodriguez, MR Lammi, C Davis, ... Journal of Allergy and Clinical Immunology 135 (2), 425-440, 2015 | 33 | 2015 |
| Microparticles in systemic sclerosis: potential pro‐inflammatory mediators and pulmonary hypertension biomarkers MR Lammi, LA Saketkoo, SC Okpechi, MA Ghonim, D Wyczechowska, ... Respirology 24 (7), 675-683, 2019 | 21 | 2019 |
| Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway MA Ghonim, J Wang, SV Ibba, HH Luu, K Pyakurel, I Benslimane, ... Journal of Translational Medicine 16, 1-12, 2018 | 19 | 2018 |
| PARP-1 is critical for recruitment of dendritic cells to the lung in a mouse model of asthma but dispensable for their differentiation and function LC Echeverri Tirado, MA Ghonim, J Wang, AA Al-Khami, ... Mediators of Inflammation 2019, 2019 | 18 | 2019 |
| ApoE deficiency promotes colon inflammation and enhances the inflammatory potential of oxidizedLDL and TNF- in primary colon epithelial cells BH El-Bahrawy A, Tarhuni A, Kim H, Subramaniam V, Benslimane I, Abd Elmajeed ... Bioscience reports, 2016 | 15 | 2016 |
| Potential of inducible Nitric Oxide synthase as a therapeutic target for allergen-induced airway hyperresponsiveness: A critical connection to Nitric Oxide levels and PARP activity I Salome’V, MA Ghonim, K Pyakurel, MR Lammi, A Mishra, AH Boulares Mediators of inflammation, 2016 | 12 | 2016 |
| Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD MR Lammi, MA Ghonim, K Pyakurel, AS Naura, SV Ibba, CJ Davis, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 310 (7 …, 2016 | 8 | 2016 |
| Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside MA Ghonim, DF Boyd, T Flerlage, PG Thomas Journal of Clinical Investigation 133 (17), e170499, 2023 | 7 | 2023 |
| Advances in chronic obstructive pulmonary disease therapy: A vascular-targeted approach SC Okpechi, MA Ghonim, MR Lammi Clinical Medicine Insights: Therapeutics 9, 1179559X17719127, 2017 | 6 | 2017 |
| Minocycline-based metronomic therapy as a novel approach to enhance anti-tumor immune responses and reduce tumor burden in mouse models of colorectal cancer SV Ibba, HH Luu, M Ghonim, C Vittori, MJ Dean, G Monticone, F Peruzzi, ... Cancer Research 82 (12_Supplement), 4211-4211, 2022 | 2 | 2022 |
| Acute effect of inhaled iloprost on exercise dynamic hyperinflation in COPD patients: A randomized crossover study MR Lammi, MA Ghonim, J Johnson, J D'Aquin, JB Zamjahn, A Pellett, ... Respiratory medicine 180, 106354, 2021 | 2 | 2021 |
| The catalytic subunit of DNA-PK has a unique function in inflammation independently of Ku70 and DNA repair: a new opportunity to target the enzyme without interfering with DNA … MA Ghonim, K Pyakurel, H Luu, S Okpechi, J Ju, H Boulares The Journal of Immunology 200 (1_Supplement), 173.18-173.18, 2018 | 2 | 2018 |
| Poly (ADP) Ribose Polymerase (PARP)‐1 Is A critical Determinant of Atopic Dermatitis through Control of Allergen‐Induced Th2 And T‐regulatory Responses And Expression of The … MA Ghonim, MM Abouzeid, K Pyakurel, J Wang, A Tarhuni, H Boulares The FASEB Journal 31, 995.13-995.13, 2017 | 2 | 2017 |
| PARP-1 and methods of use thereof H Boulares, M Ghonim, A Al-Khami, A Ochoa US Patent 11,723,906, 2023 | 1 | 2023 |
| Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly (ADP-ribosyl) ation, calpains and autophagy J Wang, MA Ghonim, SV Ibba, HH Luu, Y Aydin, PA Greer, AH Boulares Journal of Translational Medicine 20 (1), 521, 2022 | 1 | 2022 |
Amir Al-KhamiPrincipal Scientist, Pfizer Cancer Immunology DiscoveryEmail verificata su pfizer.com
