Ben Lehner
Ben Lehner
Altri nomiORCID: 0000-0002-8817-1124
Generative and Synthetic Genomics, Wellcome Sanger Institute; Systems and Synthetic Biology, CRG
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Citata da
Citata da
3D structures of individual mammalian genomes studied by single-cell Hi-C
TJ Stevens, D Lando, S Basu, LP Atkinson, Y Cao, SF Lee, M Leeb, ...
Nature 544 (7648), 59-64, 2017
Chromatin organization is a major influence on regional mutation rates in human cancer cells
B Schuster-Bckler, B Lehner
nature 488 (7412), 504-507, 2012
Synonymous mutations frequently act as driver mutations in human cancers
F Supek, B Miana, J Valcrcel, T Gabaldn, B Lehner
Cell 156 (6), 1324-1335, 2014
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
B Lehner, C Crombie, J Tischler, A Fortunato, AG Fraser
Nature genetics 38 (8), 896-903, 2006
Intergenerational and transgenerational epigenetic inheritance in animals
MF Perez, B Lehner
Nature cell biology 21 (2), 143-151, 2019
The rules and impact of nonsense-mediated mRNA decay in human cancers
RGH Lindeboom, F Supek, B Lehner
Nature genetics 48 (10), 1112-1118, 2016
Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity
T Vavouri, JI Semple, R Garcia-Verdugo, B Lehner
Cell 138 (1), 198-208, 2009
Transgenerational transmission of environmental information in C. elegans
A Klosin, E Casas, C Hidalgo-Carcedo, T Vavouri, B Lehner
Science 356 (6335), 320-323, 2017
Differential DNA mismatch repair underlies mutation rate variation across the human genome
F Supek, B Lehner
Nature 521 (7550), 81-84, 2015
Tissue specificity and the human protein interaction network
A Bossi, B Lehner
Molecular systems biology 5 (1), 260, 2009
In search of antisense
G Lavorgna, D Dahary, B Lehner, R Sorek, CM Sanderson, G Casari
Trends in biochemical sciences 29 (2), 88-94, 2004
Molecular mechanisms of epistasis within and between genes
B Lehner
Trends in Genetics 27 (8), 323-331, 2011
A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans
I Lee, B Lehner, C Crombie, W Wong, AG Fraser, EM Marcotte
Nature genetics 40 (2), 181-188, 2008
Antisense transcripts in the human genome
B Lehner, G Williams, RD Campbell, CM Sanderson
Trends in Genetics 18 (2), 63-65, 2002
A first-draft human protein-interaction map
B Lehner, AG Fraser
Genome biology 5, 1-9, 2004
A concentration-dependent liquid phase separation can cause toxicity upon increased protein expression
B Bolognesi, NL Gotor, R Dhar, D Cirillo, M Baldrighi, GG Tartaglia, ...
Cell reports 16 (1), 222-231, 2016
Selection to minimise noise in living systems and its implications for the evolution of gene expression
B Lehner
Molecular systems biology 4 (1), 170, 2008
Genotype to phenotype: lessons from model organisms for human genetics
B Lehner
Nature Reviews Genetics 14 (3), 168-178, 2013
Predicting mutation outcome from early stochastic variation in genetic interaction partners
A Burga, MO Casanueva, B Lehner
Nature 480 (7376), 250-253, 2011
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
RGH Lindeboom, M Vermeulen, B Lehner, F Supek
Nature genetics 51 (11), 1645-1651, 2019
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
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