| T-cell invigoration to tumour burden ratio associated with anti-PD-1 response AC Huang, MA Postow, RJ Orlowski, R Mick, B Bengsch, S Manne, W Xu, ... Nature 545 (7652), 60-65, 2017 | 1485 | 2017 |
| Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K J Villanueva, A Vultur, JT Lee, R Somasundaram, M Fukunaga-Kalabis, ... Cancer cell 18 (6), 683-695, 2010 | 1477 | 2010 |
| A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma AC Huang, RJ Orlowski, X Xu, R Mick, SM George, PK Yan, S Manne, ... Nature medicine 25 (3), 454-461, 2019 | 556 | 2019 |
| BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers KN Maxwell, B Wubbenhorst, BM Wenz, D De Sloover, J Pluta, L Emery, ... Nature communications 8 (1), 319, 2017 | 274 | 2017 |
| Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma J Villanueva, JR Infante, C Krepler, P Reyes-Uribe, M Samanta, HY Chen, ... Cell reports 4 (6), 1090-1099, 2013 | 215 | 2013 |
| Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436) KL Nathanson, AM Martin, B Wubbenhorst, J Greshock, R Letrero, ... Clinical cancer research 19 (17), 4868-4878, 2013 | 193 | 2013 |
| Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target G Chen, N Chakravarti, K Aardalen, AJ Lazar, MT Tetzlaff, B Wubbenhorst, ... Clinical Cancer Research 20 (21), 5537-5546, 2014 | 189 | 2014 |
| Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas L Fishbein, S Khare, B Wubbenhorst, D DeSloover, K D’Andrea, S Merrill, ... Nature communications 6 (1), 6140, 2015 | 170 | 2015 |
| Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer KN Maxwell, B Wubbenhorst, K D’Andrea, B Garman, JM Long, J Powers, ... Genetics in medicine 17 (8), 630-638, 2015 | 161 | 2015 |
| The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk TP Slavin, KN Maxwell, J Lilyquist, J Vijai, SL Neuhausen, SN Hart, ... NPJ breast cancer 3 (1), 22, 2017 | 146 | 2017 |
| A comprehensive patient-derived xenograft collection representing the heterogeneity of melanoma C Krepler, K Sproesser, P Brafford, M Beqiri, B Garman, M Xiao, ... Cell reports 21 (7), 1953-1967, 2017 | 135 | 2017 |
| Evaluation of ACMG-guideline-based variant classification of cancer susceptibility and non-cancer-associated genes in families affected by breast cancer KN Maxwell, SN Hart, J Vijai, KA Schrader, TP Slavin, T Thomas, ... The American Journal of Human Genetics 98 (5), 801-817, 2016 | 126 | 2016 |
| Arginase 2 suppresses renal carcinoma progression via biosynthetic cofactor pyridoxal phosphate depletion and increased polyamine toxicity JD Ochocki, S Khare, M Hess, D Ackerman, B Qiu, JI Daisak, AJ Worth, ... Cell metabolism 27 (6), 1263-1280. e6, 2018 | 99 | 2018 |
| Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets VR Dondeti, B Wubbenhorst, P Lal, JD Gordan, K D'Andrea, EF Attiyeh, ... Cancer research 72 (1), 112-121, 2012 | 83 | 2012 |
| Genetic and genomic characterization of 462 melanoma patient-derived xenografts, tumor biopsies, and cell lines B Garman, IN Anastopoulos, C Krepler, P Brafford, K Sproesser, Y Jiang, ... Cell reports 21 (7), 1936-1952, 2017 | 77 | 2017 |
| Genomic signatures predict the immunogenicity of BRCA-deficient breast cancer AA Kraya, KN Maxwell, B Wubbenhorst, BM Wenz, J Pluta, AJ Rech, ... Clinical Cancer Research 25 (14), 4363-4374, 2019 | 73 | 2019 |
| Exome sequencing of filaggrin and related genes in African-American children with atopic dermatitis DJ Margolis, J Gupta, AJ Apter, O Hoffstad, M Papadopoulos, ... The Journal of investigative dermatology 134 (8), 2272, 2014 | 68 | 2014 |
| Uncommon filaggrin variants are associated with persistent atopic dermatitis in African Americans DJ Margolis, N Mitra, H Gochnauer, B Wubbenhorst, K D’Andrea, A Kraya, ... Journal of investigative dermatology 138 (7), 1501-1506, 2018 | 65 | 2018 |
| Association of inherited pathogenic variants in checkpoint kinase 2 (CHEK2) with susceptibility to testicular germ cell tumors SH AlDubayan, LC Pyle, M Gamulin, T Kulis, ND Moore, A Taylor-Weiner, ... JAMA oncology 5 (4), 514-522, 2019 | 57 | 2019 |
| Association of filaggrin loss-of-function variants with race in children with atopic dermatitis DJ Margolis, N Mitra, B Wubbenhorst, K D’Andrea, AA Kraya, O Hoffstad, ... JAMA dermatology 155 (11), 1269-1276, 2019 | 53 | 2019 |
