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Mahesh Saqcena
Mahesh Saqcena
Scientific Lead, Loxo Oncology @ Lilly
Verified email at loxooncology.com
Title
Cited by
Cited by
Year
Regulation of G1 cell cycle progression: distinguishing the restriction point from a nutrient-sensing cell growth checkpoint (s)
DA Foster, P Yellen, L Xu, M Saqcena
Genes & cancer 1 (11), 1124-1131, 2010
3132010
Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine
J Nagarajah, M Le, JA Knauf, G Ferrandino, C Montero-Conde, ...
The Journal of clinical investigation 126 (11), 4119-4124, 2016
1242016
Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1)
L Xu, D Salloum, PS Medlin, M Saqcena, P Yellen, B Perrella, DA Foster
Journal of Biological Chemistry 286 (29), 25477-25486, 2011
1182011
High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
P Yellen, M Saqcena, D Salloum, J Feng, A Preda, L Xu, ...
Cell Cycle 10 (22), 3948-3956, 2011
1162011
Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle
M Saqcena, D Menon, D Patel, S Mukhopadhyay, V Chow, DA Foster
PloS one 8 (8), e74157, 2013
942013
Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
F Parisi, S Riccardo, M Daniel, M Saqcena, N Kundu, A Pession, D Grifoni, ...
BMC biology 9, 1-13, 2011
732011
Tipifarnib inhibits HRAS-driven dedifferentiated thyroid cancers
BR Untch, V Dos Anjos, MER Garcia-Rendueles, JA Knauf, ...
Cancer Research 78 (16), 4642-4657, 2018
672018
EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC
GP Krishnamoorthy, NR Davidson, SD Leach, Z Zhao, SW Lowe, G Lee, ...
Cancer Discovery 9 (2), 264-281, 2019
662019
SWI/SNF complex mutations promote thyroid tumor progression and insensitivity to redifferentiation therapies
M Saqcena, LJ Leandro-Garcia, JLV Maag, V Tchekmedyian, ...
Cancer Discovery 11 (5), 1158-1175, 2021
632021
Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs
M Saqcena, S Mukhopadhyay, C Hosny, A Alhamed, A Chatterjee, ...
Oncogene 34 (20), 2672-2680, 2015
632015
Reciprocal regulation of AMP-activated protein kinase and phospholipase D.
S Mukhopadhyay, M Saqcena, A Chatterjee, A Garcia, MA Frias, DA Foster
Journal of Biological Chemistry, 2015
582015
Synthetic lethality in KRas-driven cancer cells created by glutamine deprivation
S Mukhopadhyay, M Saqcena, DA Foster
Oncoscience 2 (10), 807, 2015
462015
Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3β and casein kinase 1 kinases
M Galletti, S Riccardo, F Parisi, C Lora, MK Saqcena, L Rivas, B Wong, ...
Molecular and cellular biology 29 (12), 3424-3434, 2009
432009
Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle
M Saqcena, D Patel, D Menon, S Mukhopadhyay, DA Foster
Cell Cycle 14 (14), 2285-2292, 2015
342015
A late G1 lipid checkpoint that is dysregulated in clear cell renal carcinoma cells
D Patel, D Salloum, M Saqcena, A Chatterjee, V Mroz, M Ohh, DA Foster
Journal of Biological Chemistry 292 (3), 936-944, 2017
272017
Characterization of Subtypes of BRAF-Mutant Papillary Thyroid Cancer Defined by Their Thyroid Differentiation Score
L Boucai, V Seshan, M Williams, JA Knauf, M Saqcena, RA Ghossein, ...
The Journal of Clinical Endocrinology & Metabolism 107 (4), 1030-1039, 2022
202022
Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers
KA Luckett, JR Cracchiolo, GP Krishnamoorthy, LJ Leandro-Garcia, ...
Endocrine-Related Cancer 28 (6), 391-402, 2021
152021
Genomic and transcriptomic characteristics of metastatic thyroid cancers with exceptional responses to radioactive iodine therapy
L Boucai, M Saqcena, F Kuo, RK Grewal, N Socci, JA Knauf, ...
Clinical Cancer Research 29 (8), 1620-1630, 2023
142023
Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors
MER Garcia-Rendueles, G Krishnamoorthy, M Saqcena, A Acuña-Ruiz, ...
Molecular Cancer 21 (1), 213, 2022
112022
RBM10 loss in thyroid cancer leads to aberrant splicing of cytoskeletal and extracellular matrix mRNAs and increased metastatic fitness
GP Krishnamoorthy, A Glover, B Untch, M Saqcena, D Vukel, K Berman, ...
Cancer Research 82 (12_Supplement), 986-986, 2022
32022
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