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Mehdi Chaib
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Immunometabolism: from basic mechanisms to translation
L Makowski, M Chaib, JC Rathmell
Immunological reviews 295 (1), 5-14, 2020
2572020
Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti‐tumor immunity
LM Sipe, M Chaib, AK Pingili, JF Pierre, L Makowski
Immunological Reviews 295 (1), 220-239, 2020
512020
Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer
AK Pingili, M Chaib, LM Sipe, EJ Miller, B Teng, R Sharma, JR Yarbro, ...
Cell reports 35 (12), 2021
502021
Friend or foe? Recent strategies to target myeloid cells in cancer
M Chaib, SC Chauhan, L Makowski
Frontiers in Cell and Developmental Biology 8, 351, 2020
472020
TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response
AS Meena, PK Shukla, B Bell, F Giorgianni, R Caires, C Fernández-Peña, ...
Cell reports 39 (11), 2022
142022
TGF-β alters the proportion of infiltrating immune cells in a pancreatic ductal adenocarcinoma
K Trebska-McGowan, M Chaib, MA Alvarez, R Kansal, AK Pingili, ...
Journal of Gastrointestinal Surgery 26 (1), 113-121, 2022
142022
Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery
LM Sipe, M Chaib, EB Korba, H Jo, MC Lovely, BR Counts, U Tanveer, ...
Elife 11, e79143, 2022
122022
PKC agonism restricts innate immune suppression, promotes antigen cross-presentation and synergizes with agonistic CD40 antibody therapy to activate CD8+ T cells in breast cancer
M Chaib, LM Sipe, JR Yarbro, MS Bohm, BR Counts, U Tanveer, ...
Cancer letters 531, 98-108, 2022
92022
The pancreatic cancer immune tumor microenvironment is negatively remodeled by gemcitabine while TGF‐β receptor plus dual checkpoint inhibition maintains antitumor immune cells
M Rana, R Kansal, M Chaib, B Teng, M Morrrison, DN Hayes, AG Stanfill, ...
Molecular Carcinogenesis 61 (6), 549-557, 2022
82022
Reprogramming of pancreatic adenocarcinoma immunosurveillance by a microbial probiotic siderophore
M Chaib, BB Hafeez, H Mandil, D Daria, AK Pingili, S Kumari, M Sikander, ...
Communications Biology 5 (1), 1181, 2022
62022
Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer
M Chaib, JR Holt, EL Fisher, LM Sipe, MS Bohm, SC Joseph, ...
Science Advances 9 (51), eadd3231, 2023
32023
Myeloid cells in the era of cancer Immunotherapy: top 3 unanswered questions
M Chaib, UA Tanveer, L Makowski
Pharmacology & Therapeutics 244, 108370, 2023
22023
Myeloid PKCd activation inhibits innate immune suppression and promotes antigen cross-presentation in triple negative breast cancer
M Chaib, J Holt, L Sipe, A Pingili, TJ Hollingsworth, D Daria, N Hayes, ...
Cancer Research 81 (13_Supplement), 118-118, 2021
12021
Abstract LB-A33: Mitogen activated protein kinase (MAPK) signaling in neprilysin-hypermethylated breast cancer
C Reagor, M Chaib, RE Conway
Molecular Cancer Therapeutics 17 (1_Supplement), LB-A33-LB-A33, 2018
12018
Cucurbitacin B: A novel agent for inducing tumor-immune response.
SS Alvi, E Anning, M Ahmad, C Perez, M Chaib, SC Chuahan, ...
2024
Cucurbitacin B: A promising drug candidate for targeting tumor immunosuppressive cells
EB Anning, M Ahmad, S Alvi, C Parez, M Chaib, D Bansal, D Kim, ...
Cancer Research 83 (7_Supplement), 4427-4427, 2023
2023
Targeting tumor associated macrophages to improve the immunotherapy of pancreatic cancer
M Chaib, MM Yallapu, M Jaggi, SC Chauhan, BB Hafeez
2023
The Gut Microbiome and Metabolic Surgery
M Chaib, MJ Davis, S Kubovec, L Makowski, JF Pierre
2022
Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer
M Chaib
The University of Tennessee Health Science Center, 2022
2022
Fr642 TGF-β RECEPTOR INHIBITION ENHANCES DUAL-IMMUNE CHECKPOINT INHIBITION THERAPY IN PANCREATIC CANCER
RG Kansal, M Rana, M Chaib, D Shibata, L Makowski, ES Glazer
Gastroenterology 160 (6), S-915, 2021
2021
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Articles 1–20