Andrea Testa
Andrea Testa
Amphista Therapeutics
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Structural basis of PROTAC cooperative recognition for selective protein degradation
MS Gadd, A Testa, X Lucas, KH Chan, W Chen, DJ Lamont, M Zengerle, ...
Nature Chemical Biology 13 (5), 514-521, 2017
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
C Maniaci, SJ Hughes, A Testa, W Chen, DJ Lamont, S Rocha, DR Alessi, ...
Nature communications 8 (1), 1-14, 2017
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based…
V Zoppi, SJ Hughes, C Maniaci, A Testa, T Gmaschitz, C Wieshofer, ...
Journal of medicinal chemistry 62 (2), 699-726, 2018
Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1…
KH Chan, M Zengerle, A Testa, A Ciulli
Journal of medicinal chemistry 61 (2), 504-513, 2018
Structure‐Based Design of a Macrocyclic PROTAC
A Testa, SJ Hughes, X Lucas, JE Wright, A Ciulli
Angewandte Chemie 132 (4), 1744-1751, 2020
Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
M Girardini, C Maniaci, SJ Hughes, A Testa, A Ciulli
Bioorganic & medicinal chemistry 27 (12), 2466-2479, 2019
3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation
A Testa, X Lucas, GV Castro, KH Chan, JE Wright, AC Runcie, MS Gadd, ...
Journal of the American Chemical Society 140 (29), 9299-9313, 2018
Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader
H Tovell, A Testa, C Maniaci, H Zhou, AR Prescott, T Macartney, A Ciulli, ...
ACS chemical biology 14 (5), 882-892, 2019
Design and characterization of SGK3-PROTAC1, an isoform specific SGK3 kinase PROTAC degrader
H Tovell, A Testa, H Zhou, N Shpiro, C Crafter, A Ciulli, DR Alessi
ACS chemical biology 14 (9), 2024-2034, 2019
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity
S Imaide, KM Riching, N Makukhin, V Vetma, C Whitworth, SJ Hughes, ...
Nature chemical biology 17 (11), 1157-1167, 2021
Understanding and improving the membrane permeability of VH032-based PROTACs
VG Klein, CE Townsend, A Testa, M Zengerle, C Maniaci, SJ Hughes, ...
ACS medicinal chemistry letters 11 (9), 1732-1738, 2020
New molecular and therapeutic insights into canine diffuse large B cell lymphoma elucidates the role of the dog as a model for human disease
L Aresu, S Ferraresso, L Marconato, L Cascione, S Napoli, E Gaudio, ...
Blood 132, 4173, 2018
PET Tracers To Study Clinically Relevant Hepatic Transporters
A Testa, M Zanda, CS Elmore, P Sharma
Molecular pharmaceutics 12 (7), 2203-2216, 2015
Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition
AC Runcie, M Zengerle, KH Chan, A Testa, L van Beurden, MGJ Baud, ...
Chemical Science 9 (9), 2452-2468, 2018
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
LM Simpson, TJ Macartney, A Nardin, LJ Fulcher, S Rth, A Testa, ...
Cell Chemical Biology, 2020
The rise and rise of protein degradation: Opportunities and challenges ahead
SJ Hughes, A Testa, N Thompson, I Churcher
Drug discovery today 26 (12), 2889-2897, 2021
Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements
FE Morreale, A Testa, VK Chaugule, A Bortoluzzi, A Ciulli, H Walden
Journal of medicinal chemistry 60 (19), 8183-8191, 2017
Diastereoselective Protocols for the Synthesis of 2, 3-trans-and 2, 3-cis-6-Methoxy-morpholine-2-carboxylic Acid Derivatives
M Penso, F Foschi, S Pellegrino, A Testa, ML Gelmi
The Journal of organic chemistry 77 (7), 3454-3461, 2012
Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins
AG Bond, C Craigon, KH Chan, A Testa, A Karapetsas, R Fasimoye, ...
Journal of Medicinal Chemistry 64 (20), 15477-15502, 2021
Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters
A Testa, S Dall’Angelo, M Mingarelli, A Augello, L Schweiger, A Welch, ...
Bioorganic & medicinal chemistry 25 (3), 963-976, 2017
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
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