Cheryl Arrowsmith
Cheryl Arrowsmith
Senior Scientist, Princess Margaret Cancer Centre & Professor of Medical Biophysics, University of Toronto
Verified email at uhnres.utoronto.ca
TitleCited byYear
Epigenetic protein families: a new frontier for drug discovery
CH Arrowsmith, C Bountra, PV Fish, K Lee, M Schapira
Nature reviews Drug discovery 11 (5), 384, 2012
10672012
Histone recognition and large-scale structural analysis of the human bromodomain family
P Filippakopoulos, S Picaud, M Mangos, T Keates, JP Lambert, ...
Cell 149 (1), 214-231, 2012
9082012
Consistent blind protein structure generation from NMR chemical shift data
Y Shen, O Lange, F Delaglio, P Rossi, JM Aramini, G Liu, A Eletsky, Y Wu, ...
Proceedings of the National Academy of Sciences 105 (12), 4685-4690, 2008
7292008
Protein production and purification
S Gräslund, P Nordlund, J Weigelt, BM Hallberg, J Bray, O Gileadi, ...
Nature methods 5 (2), 135, 2008
6732008
A suite of triple resonance NMR experiments for the backbone assignment of 15N, 13C, 2H labeled proteins with high sensitivity
T Yamazaki, W Lee, CH Arrowsmith, DR Muhandiram, LE Kay
Journal of the American Chemical Society 116 (26), 11655-11666, 1994
5831994
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty, ...
Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006
5392006
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
DB Yap, J Chu, T Berg, M Schapira, SWG Cheng, A Moradian, RD Morin, ...
Blood 117 (8), 2451-2459, 2011
4712011
ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly (ADP‐ribose) polymerase
H Vaziri, MD West, RC Allsopp, TS Davison, YS Wu, CH Arrowsmith, ...
The EMBO journal 16 (19), 6018-6033, 1997
4541997
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536, 2015
4052015
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1
GV Avvakumov, JR Walker, S Xue, Y Li, S Duan, C Bronner, ...
Nature 455 (7214), 822, 2008
3902008
Structural proteomics of an archaeon
D Christendat, A Yee, A Dharamsi, Y Kluger, A Savchenko, JR Cort, ...
Nature Structural & Molecular Biology 7 (10), 903, 2000
3802000
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566, 2011
3792011
Self-renewal as a therapeutic target in human colorectal cancer
A Kreso, P Van Galen, NM Pedley, E Lima-Fernandes, C Frelin, T Davis, ...
Nature medicine 20 (1), 29, 2014
3522014
Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1: implications for EBV-mediated immortalization
V Saridakis, Y Sheng, F Sarkari, MN Holowaty, K Shire, T Nguyen, ...
Molecular cell 18 (1), 25-36, 2005
3082005
Latent and active p53 are identical in conformation
A Ayed, FAA Mulder, GS Yi, Y Lu, LE Kay, CH Arrowsmith
Nature Structural & Molecular Biology 8 (9), 756, 2001
3072001
Solution structure of the tetrameric minimum transforming domain of p53
W Lee, TS Harvey, Y Yin, P Yau, D Litchfield, CH Arrowsmith
Nature structural biology 1 (12), 877, 1994
3021994
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
2962013
Placental transforming growth factor-β is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression
PX Li, J Wong, A Ayed, D Ngo, AM Brade, C Arrowsmith, RC Austin, ...
Journal of Biological Chemistry 275 (26), 20127-20135, 2000
2832000
Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin
PM Hwang, N Zhou, X Shan, CH Arrowsmith, HJ Vogel
Biochemistry 37 (12), 4288-4298, 1998
2771998
Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
E Bochkareva, L Kaustov, A Ayed, GS Yi, Y Lu, A Pineda-Lucena, ...
Proceedings of the National Academy of Sciences 102 (43), 15412-15417, 2005
2602005
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