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Robert E. Hughes
Robert E. Hughes
Vice President of Biochemistry, BioAge Labs
Verified email at bioagelabs.com - Homepage
Title
Cited by
Cited by
Year
A protein interaction network of the malaria parasite Plasmodium falciparum
DJ LaCount, M Vignali, R Chettier, A Phansalkar, R Bell, JR Hesselberth, ...
Nature 438 (7064), 103-107, 2005
6342005
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
LS Kaltenbach, E Romero, RR Becklin, R Chettier, R Bell, A Phansalkar, ...
PLoS genetics 3 (5), e82, 2007
5242007
Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype
RM Laberge, L Zhou, MR Sarantos, F Rodier, A Freund, PLJ de Keizer, ...
Aging cell 11 (4), 569-578, 2012
2342012
Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease
JP Miller, J Holcomb, I Al-Ramahi, M De Haro, J Gafni, N Zhang, E Kim, ...
Neuron 67 (2), 199-212, 2010
2062010
Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm
E Romero, GH Cha, P Verstreken, CV Ly, RE Hughes, HJ Bellen, J Botas
Neuron 57 (1), 27-40, 2008
1882008
Systematic and large-scale two-hybrid screens
P Uetz, RE Hughes
Current opinion in microbiology 3 (3), 303-308, 2000
1882000
Proteomic analysis of age‐dependent changes in protein solubility identifies genes that modulate lifespan
P Reis‐Rodrigues, G Czerwieniec, TW Peters, US Evani, S Alavez, ...
Aging cell 11 (1), 120-127, 2012
1852012
Calcium binding, but not a calcium-myristoyl switch, controls the ability of guanylyl cyclase-activating protein GCAP-2 to regulate photoreceptor guanylyl cyclase
EV Olshevskaya, RE Hughes, JB Hurley, AM Dizhoor
Journal of Biological Chemistry 272 (22), 14327-14333, 1997
1461997
A human protein interaction network shows conservation of aging processes between human and invertebrate species
R Bell, A Hubbard, R Chettier, D Chen, JP Miller, P Kapahi, ...
PLoS genetics 5 (3), e1000414, 2009
1422009
Altered transcription in yeast expressing expanded polyglutamine
RE Hughes, RS Lo, C Davis, AD Strand, CL Neal, JM Olson, S Fields
Proceedings of the National Academy of Sciences 98 (23), 13201-13206, 2001
1372001
A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease*♦
C Tourette, B Li, R Bell, S O'Hare, LS Kaltenbach, SD Mooney, ...
Journal of Biological Chemistry 289 (10), 6709-6726, 2014
1052014
Cooperativity mutants of the γδ resolvase identify an essential interdimer interaction
RE Hughes, GF Hatfull, P Rice, TA Steitz, NDF Grindley
Cell 63 (6), 1331-1338, 1990
1001990
Therapeutic opportunities in polyglutamine disease
RE Hughes, JM Olson
Nature medicine 7 (4), 419-423, 2001
902001
A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components
C Gorbea, G Pratt, V Ustrell, R Bell, S Sahasrabudhe, RE Hughes, ...
Journal of biological chemistry 285 (41), 31616-31633, 2010
862010
Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening
AL Orr, D Ashok, MR Sarantos, T Shi, RE Hughes, MD Brand
Free Radical Biology and Medicine 65, 1047-1059, 2013
842013
Protein‐protein interactions directing resolvase site‐specific recombination: a structure‐function analysis.
RE Hughes, PA Rice, TA Steitz, ND Grindley
The EMBO Journal 12 (4), 1447-1458, 1993
711993
Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR)
P Agrawal, YT Chen, B Schilling, BW Gibson, RE Hughes
Journal of Biological Chemistry 287 (25), 21164-21175, 2012
692012
Calcium-dependent solvation of the myristoyl group of recoverin
RE Hughes, PS Brzovic, RE Klevit, JB Hurley
Biochemistry 34 (36), 11410-11416, 1995
581995
Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase
AL Orr, D Ashok, MR Sarantos, R Ng, T Shi, AA Gerencser, RE Hughes, ...
PLoS One 9 (2), e89938, 2014
562014
A genome-scale RNA–Interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease
JP Miller, BE Yates, I Al-Ramahi, AE Berman, M Sanhueza, E Kim, ...
PLoS genetics 8 (11), e1003042, 2012
532012
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