Segui
Zhen Wang
Zhen Wang
Lingang Laboratory
Email verificata su lglab.ac.cn
Titolo
Citata da
Citata da
Anno
Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors
Z Xu, Z Liu, T Chen, TT Chen, Z Wang, G Tian, J Shi, X Wang, Y Lu, X Yan, ...
Journal of medicinal chemistry 54 (15), 5607-5611, 2011
1322011
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2
Y Xie, W Yin, Y Zhang, W Shang, Z Wang, X Luan, G Tian, HA Aisa, Y Xu, ...
Cell Research 31 (11), 1212-1214, 2021
832021
An open, prospective cohort study of VV116 in Chinese participants infected with SARS-CoV-2 omicron variants
Y Shen, J Ai, N Lin, H Zhang, Y Li, H Wang, S Wang, Z Wang, T Li, F Sun, ...
Emerging microbes & infections 11 (1), 1518-1523, 2022
502022
Thermodynamic and structural characterization of halogen bonding in protein–ligand interactions: a case study of PDE5 and its inhibitors
J Ren, Y He, W Chen, T Chen, G Wang, Z Wang, Z Xu, X Luo, W Zhu, ...
Journal of medicinal chemistry 57 (8), 3588-3593, 2014
472014
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects
H Qian, Y Wang, M Zhang, Y Xie, Q Wu, L Liang, Y Cao, H Duan, G Tian, ...
Acta Pharmacologica Sinica 43 (12), 3130-3138, 2022
432022
Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice
H Yu, M Li, D Zhou, D Lv, Q Liao, Z Lou, M Shen, Z Wang, M Li, X Xiao, ...
Neuropharmacology 131, 209-222, 2018
392018
Multiple pharmacophore models combined with molecular docking: a reliable way for efficiently identifying novel PDE4 inhibitors with high structural diversity
Z Chen, G Tian, Z Wang, H Jiang, J Shen, W Zhu
Journal of chemical information and modeling 50 (4), 615-625, 2010
392010
Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase …
Y Mao, W Zhu, X Kong, Z Wang, H Xie, J Ding, NK Terrett, J Shen, J Shen
Bioorganic & medicinal chemistry 21 (11), 3090-3104, 2013
352013
Automated design and optimization of multitarget schizophrenia drug candidates by deep learning
X Tan, X Jiang, Y He, F Zhong, X Li, Z Xiong, Z Li, X Liu, C Cui, Q Zhao, ...
European Journal of Medicinal Chemistry 204, 112572, 2020
322020
Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5
G Wang, Z Liu, T Chen, Z Wang, H Yang, M Zheng, J Ren, G Tian, X Yang, ...
Journal of Medicinal Chemistry 55 (23), 10540-10550, 2012
322012
2-Phenylquinazolin-4 (3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6
H Duan, J Zheng, Q Lai, Z Liu, G Tian, Z Wang, J Li, J Shen
Bioorganic & medicinal chemistry letters 19 (10), 2777-2779, 2009
292009
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment …
Z Wang, X Jiang, X Zhang, G Tian, R Yang, J Wu, X Zou, Z Liu, X Yang, ...
Journal of Medicinal Chemistry 62 (10), 4979-4990, 2019
252019
Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF …
C Wu, Y Wang, Y He, S Wu, Z Xie, J Zhang, J Shen, Z Wang, L He
Neurobiology of learning and memory 167, 107136, 2020
232020
Targeted drugs for treatment of pulmonary arterial hypertension: past, present, and future perspectives
W Zheng, Z Wang, X Jiang, Q Zhao, J Shen
Journal of Medicinal Chemistry 63 (24), 15153-15186, 2020
222020
GLYX-13 ameliorates schizophrenia-like phenotype induced by MK-801 in mice: role of hippocampal NR2B and DISC1
D Zhou, D Lv, Z Wang, Y Zhang, Z Chen, C Wang
Frontiers in Molecular Neuroscience 11, 121, 2018
212018
Essential roles of neuropeptide VGF regulated TrkB/mTOR/BICC1 signaling and phosphorylation of AMPA receptor subunit GluA1 in the rapid antidepressant-like actions of ketamine …
M Shen, D Lv, X Liu, S Li, Y Chen, Y Zhang, Z Wang, C Wang
Brain Research Bulletin 143, 58-65, 2018
182018
Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect
M Xu, Y Wang, F Yang, C Wu, Z Wang, B Ye, X Jiang, Q Zhao, J Li, Y Liu, ...
European journal of medicinal chemistry 145, 74-85, 2018
172018
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics
H Xiamuxi, Z Wang, J Li, Y Wang, C Wu, F Yang, X Jiang, Y Liu, Q Zhao, ...
Bioorganic & Medicinal Chemistry 25 (17), 4904-4916, 2017
142017
The selectivity and potency of the new PDE5 inhibitor TPN729MA
Z Wang, D Zhu, X Yang, J Li, X Jiang, G Tian, NK Terrett, J Jin, H Wu, ...
The journal of sexual medicine 10 (11), 2790-2797, 2013
142013
Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs
M Xu, Y Wang, F Yang, C Wu, Z Wang, B Ye, X Jiang, Q Zhao, J Li, Y Liu, ...
Bioorganic & Medicinal Chemistry Letters 28 (4), 606-611, 2018
122018
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