| Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms GI Lepesheva, MR Waterman Biochimica et biophysica acta (BBA)-General subjects 1770 (3), 467-477, 2007 | 512 | 2007 |
| Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis TY Hargrove, L Friggeri, Z Wawrzak, A Qi, WJ Hoekstra, RJ Schotzinger, ... Journal of Biological Chemistry 292 (16), 6728-6743, 2017 | 303 | 2017 |
| The first virally encoded cytochrome p450 DC Lamb, L Lei, AGS Warrilow, GI Lepesheva, JGL Mullins, ... Journal of virology 83 (16), 8266-8269, 2009 | 212 | 2009 |
| Rational modification of a candidate cancer drug for use against Chagas disease JM Kraus, CLMJ Verlinde, M Karimi, GI Lepesheva, MH Gelb, FS Buckner Journal of medicinal chemistry 52 (6), 1639-1647, 2009 | 177 | 2009 |
| Structural insights into inhibition of sterol 14α-demethylase in the human pathogen Trypanosoma cruzi GI Lepesheva, TY Hargrove, S Anderson, Y Kleshchenko, V Furtak, ... Journal of Biological Chemistry 285 (33), 25582-25590, 2010 | 163 | 2010 |
| CYP51—the omnipotent P450 GI Lepesheva, MR Waterman Molecular and cellular endocrinology 215 (1-2), 165-170, 2004 | 160 | 2004 |
| Sterol 14α-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth GI Lepesheva, RD Ott, TY Hargrove, YY Kleshchenko, I Schuster, WD Nes, ... Chemistry & biology 14 (11), 1283-1293, 2007 | 158 | 2007 |
| Structure-functional characterization of cytochrome P450 sterol 14α-demethylase (CYP51B) from Aspergillus fumigatus and molecular basis for the development of antifungal drugs TY Hargrove, Z Wawrzak, DC Lamb, FP Guengerich, GI Lepesheva Journal of Biological Chemistry 290 (39), 23916-23934, 2015 | 150 | 2015 |
| Structural basis for conservation in the CYP51 family GI Lepesheva, MR Waterman Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1814 (1), 88-93, 2011 | 148 | 2011 |
| CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B′ helix defines substrate preferences of sterol 14α-demethylase GI Lepesheva, NG Zaitseva, WD Nes, W Zhou, M Arase, J Liu, GC Hill, ... Journal of Biological Chemistry 281 (6), 3577-3585, 2006 | 145 | 2006 |
| Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections*♦ GI Lepesheva, HW Park, TY Hargrove, B Vanhollebeke, Z Wawrzak, ... Journal of biological chemistry 285 (3), 1773-1780, 2010 | 132 | 2010 |
| Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51) GI Lepesheva, F Villalta, MR Waterman Advances in parasitology 75, 65-87, 2011 | 130 | 2011 |
| Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis G I Lepesheva, M R Waterman Current topics in medicinal chemistry 11 (16), 2060-2071, 2011 | 124 | 2011 |
| CYP51: A major drug target in the cytochrome P450 superfamily GI Lepesheva, TY Hargrove, Y Kleshchenko, WD Nes, F Villalta, ... Lipids 43, 1117-1125, 2008 | 119 | 2008 |
| VNI cures acute and chronic experimental Chagas disease F Villalta, MC Dobish, PN Nde, YY Kleshchenko, TY Hargrove, ... The Journal of infectious diseases 208 (3), 504-511, 2013 | 118 | 2013 |
| Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14α-demethylase (CYP51) from Leishmania infantum TY Hargrove, Z Wawrzak, J Liu, WD Nes, MR Waterman, GI Lepesheva Journal of Biological Chemistry 286 (30), 26838-26848, 2011 | 118 | 2011 |
| Estriol bound and ligand-free structures of sterol 14α-demethylase LM Podust, LV Yermalitskaya, GI Lepesheva, VN Podust, EA Dalmasso, ... Structure 12 (11), 1937-1945, 2004 | 105 | 2004 |
| CYP51 as drug targets for fungi and protozoan parasites: past, present and future GI Lepesheva, L Friggeri, MR Waterman Parasitology 145 (14), 1820-1836, 2018 | 103 | 2018 |
| Conservation in the CYP51 family. Role of the B ‘helix/BC loop and helices F and G in enzymatic function GI Lepesheva, C Virus, MR Waterman Biochemistry 42 (30), 9091-9101, 2003 | 100 | 2003 |
| Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity TY Hargrove, Z Wawrzak, PW Alexander, JH Chaplin, M Keenan, ... Journal of Biological Chemistry 288 (44), 31602-31615, 2013 | 95 | 2013 |
