| 5-Aryl-pyrazolo [3, 4-b] pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3) J Witherington, V Bordas, SL Garland, DMB Hickey, RJ Ife, J Liddle, ... Bioorganic & medicinal chemistry letters 13 (9), 1577-1580, 2003 | 243 | 2003 |
| Are GPCRs still a source of new targets? SL Garland Journal of biomolecular screening 18 (9), 947-966, 2013 | 207 | 2013 |
| Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design DE Gloriam, SM Foord, FE Blaney, SL Garland Journal of medicinal chemistry 52 (14), 4429-4442, 2009 | 126 | 2009 |
| Imidazopyridine derivatives as kinase inhibitors N Bailey, MJ Bamford, H Cui, S Garland, KB Goodman, MA Hilfiker, D Lee, ... US Patent 7,348,339, 2008 | 53 | 2008 |
| 2-(4-amino-furazan-3-yl)-1-ethyl-N-[(2R)-2-morpholinylmethyl]-1H-imidazo [4, 5-c] pyridine-7-carboxamide; Mitogen-and Stress-Activated Protein (MSK) and Rho (guanosine … N Bailey, M Bamford, H Cui, S Garland, K Goodman, M Hilfiker, D Lee, ... US Patent App. 10/508,760, 2003 | 53* | 2003 |
| (1H-Imidazo [4, 5-c] pyridin-2-yl)-1, 2, 5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors MJ Bamford, MJ Alberti, N Bailey, S Davies, DK Dean, A Gaiba, S Garland, ... Bioorganic & medicinal chemistry letters 15 (14), 3402-3406, 2005 | 51 | 2005 |
| Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74 PS Miller, J Barwell, DR Poyner, MJ Wigglesworth, SL Garland, ... Biochemical and biophysical research communications 391 (1), 437-442, 2010 | 44 | 2010 |
| Design criteria for molecular mimics of fragments of the β-turn. 1. Cα atom analysis SL Garland, PM Dean Journal of computer-aided molecular design 13 (5), 469-483, 1999 | 41 | 1999 |
| The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2 PL D’Alessandro, C Corti, A Roth, A Ugolini, A Sava, D Montanari, ... Bioorganic & medicinal chemistry letters 20 (2), 759-762, 2010 | 29 | 2010 |
| Design criteria for molecular mimics of fragments of the β-turn. 2. Cα–Cβ bond vector analysis SL Garland, PM Dean Journal of computer-aided molecular design 13 (5), 485-498, 1999 | 24 | 1999 |
| An industrial perspective on positive allosteric modulation as a means to discover safe and selective drugs M Rocheville, SL Garland Drug Discovery Today: Technologies 7 (1), e87-e94, 2010 | 18 | 2010 |
| The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor B Wroblowski, MJ Wigglesworth, PG Szekeres, GD Smith, SS Rahman, ... Journal of medicinal chemistry 52 (3), 818-825, 2009 | 17 | 2009 |
| A ligand's view of target similarity: chemogenomic binding site-directed techniques for drug discovery S L Garland, D E Gloriam Current topics in medicinal chemistry 11 (15), 1872-1881, 2011 | 16 | 2011 |
| Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine PL Nichols, J Brand, M Briggs, M D’Angeli, J Farge, SL Garland, ... Bioorganic & medicinal chemistry letters 20 (4), 1368-1372, 2010 | 16 | 2010 |
| Pyrazolopyridines and pyrazolopyridazines as antidiabetics S Garland, D Haigh, DMB Hickey, J Liddle, DG Smith, RW Ward, ... US Patent 7,297,792, 2007 | 14 | 2007 |
| Pyrazolopyridines and pyrazolopyridazines as antidiabetics S Garland, D Haigh, DMB Hickey, J Liddle, DG Smith, RW Ward, ... US Patent 7,109,199, 2006 | 14 | 2006 |
| Methods for the successful application of chemogenomics to GPCR drug design. SL Garland, DE Gloriam Current topics in medicinal chemistry 11 (15), 1870, 2011 | 12 | 2011 |
| Medicaments M Alberti, S Garland, D Jung, J Veal, J Witherington US Patent App. 10/508,592, 2005 | 12 | 2005 |
| Seven transmembrane G protein-coupled receptors: insights for drug design from structure and modeling N Barton, FE Blaney, S Garland, B Tehan, I Wall Comp. Med. Chem. II 4, 669-701, 2007 | 11 | 2007 |
| The creation and characterisation of a National Compound Collection: the Royal Society of Chemistry pilot DM Andrews, LM Broad, PJ Edwards, DNA Fox, T Gallagher, SL Garland, ... Chemical Science 7 (6), 3869-3878, 2016 | 7 | 2016 |
Mark WigglesworthAlderley Lighthouse LabsVerified email at alderleylighthouselabs.com
