Devin Sok
Devin Sok
Director Antibody Discovery, International AIDS Vaccine Initiative
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Crystal structure of a soluble cleaved HIV-1 envelope trimer
JP Julien, A Cupo, D Sok, RL Stanfield, D Lyumkis, MC Deller, PJ Klasse, ...
Science 342 (6165), 1477-1483, 2013
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
TF Rogers, F Zhao, D Huang, N Beutler, A Burns, WT He, O Limbo, ...
Science 369 (6506), 956-963, 2020
Rational HIV immunogen design to target specific germline B cell receptors
J Jardine, JP Julien, S Menis, T Ota, O Kalyuzhniy, A McGuire, D Sok, ...
Science 340 (6133), 711-716, 2013
HIV-1 neutralizing antibodies induced by native-like envelope trimers
RW Sanders, MJ van Gils, R Derking, D Sok, TJ Ketas, JA Burger, ...
Science 349 (6244), 2015
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
JP Julien, D Sok, R Khayat, JH Lee, KJ Doores, LM Walker, A Ramos, ...
PLoS pathogens 9 (5), e1003342, 2013
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
JG Jardine, T Ota, D Sok, M Pauthner, DW Kulp, O Kalyuzhniy, PD Skog, ...
Science 349 (6244), 156-161, 2015
Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers
D Marrinucci, K Bethel, A Kolatkar, MS Luttgen, M Malchiodi, F Baehring, ...
Physical biology 9 (1), 016003, 2012
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
JG Jardine, DW Kulp, C Havenar-Daughton, A Sarkar, B Briney, D Sok, ...
Science 351 (6280), 1458-1463, 2016
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
D Sok, MJ van Gils, M Pauthner, JP Julien, KL Saye-Francisco, J Hsueh, ...
Proceedings of the National Academy of Sciences 111 (49), 17624-17629, 2014
Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
A Escolano, JM Steichen, P Dosenovic, DW Kulp, J Golijanin, D Sok, ...
Cell 166 (6), 1445-1458. e12, 2016
Structural basis of a shared antibody response to SARS-CoV-2
M Yuan, H Liu, NC Wu, CCD Lee, X Zhu, F Zhao, D Huang, W Yu, Y Hua, ...
Science 369 (6507), 1119-1123, 2020
Structural evolution of glycan recognition by a family of potent HIV antibodies
F Garces, D Sok, L Kong, R McBride, HJ Kim, KF Saye-Francisco, ...
Cell 159 (1), 69-79, 2014
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
D Sok, U Laserson, J Laserson, Y Liu, F Vigneault, JP Julien, B Briney, ...
PLoS pathogens 9 (11), e1003754, 2013
Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies
B Briney, D Sok, JG Jardine, DW Kulp, P Skog, S Menis, R Jacak, ...
Cell 166 (6), 1459-1470. e11, 2016
Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches
M Pauthner, C Havenar-Daughton, D Sok, JP Nkolola, R Bastidas, ...
Immunity 46 (6), 1073-1088. e6, 2017
Recent progress in broadly neutralizing antibodies to HIV
D Sok, DR Burton
Nature immunology 19 (11), 1179-1188, 2018
Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV
D Sok, KJ Doores, B Briney, KM Le, KL Saye-Francisco, A Ramos, ...
Science translational medicine 6 (236), 236ra63-236ra63, 2014
Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak
ZA Bornholdt, HL Turner, CD Murin, W Li, D Sok, CA Souders, AE Piper, ...
Science 351 (6277), 1078-1083, 2016
Holes in the glycan shield of the native HIV envelope are a target of trimer-elicited neutralizing antibodies
LE McCoy, MJ van Gils, G Ozorowski, T Messmer, B Briney, JE Voss, ...
Cell reports 16 (9), 2327-2338, 2016
Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR
SA Kazane, D Sok, EH Cho, ML Uson, P Kuhn, PG Schultz, VV Smider
Proceedings of the National Academy of Sciences 109 (10), 3731-3736, 2012
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